Scalability of Heterocyclic Microwave-Assisted Transformations From Batch to Continuous Flow - A Case Study
Poster May 07, 2006
Jennifer M. Kremsner, Bimbisar Desai, Alexander Stadler and C. Oliver Kappe
Herein we present a case study on the small to large scale microwave-assisted synthesis of the DHPM 4 under batch and continuous flow conditions in monomode and multimode cavities.
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE