We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Screening and Profiling for Kinases: Development of a Unique and Versatile Platform
Poster

Screening and Profiling for Kinases: Development of a Unique and Versatile Platform

Screening and Profiling for Kinases: Development of a Unique and Versatile Platform
Poster

Screening and Profiling for Kinases: Development of a Unique and Versatile Platform

Abstract

To build a unique kinase platform providing reliable and quantitative data, we have designed a flexible system with well-defined yet different assay conditions for each kinase. This platform minimizes interferences, including those from test compounds, and displays a homogeneous and generic assay format.

After reviewing available assay technologies, Homogeneous Time Resolved Fluorescence (HTRF) was selected as that which best met our requirements. To date, 70 kinase assays have been developed on this model. Using pertinent examples, we will illustrate how this technology supports and serves scientific drug discovery, and allows direct and obvious comparison across the panel for both high throughput compound profiling and high throughput screening.

Advertisement