Selective Debenzylation of N-Benzyloxypyrazinones in Flow
Poster Feb 16, 2016
Anh Hung MAI - Cedrick VERYSER - Wim DE BORGGRAEVE
By using flow technology, we have succeeded in delivering a reproducible methodology for the selective debenzylation of O-benzyl protected cyclic hydroxamates, with a potential of scaling up from milligram scale to gram scale via suitable flow operations. This solved reproducibility problems experienced earlier using batch reaction conditions and finally allowed the efficient, safe, and reproducible synthesis of a library of 28 N-hydroxypyrazin-2(1H)-one analogues.
New Biotransformation Prediction Engine Integrated into a Metabolite Identification SolutionPoster
Here we present a new prediction algorithm that determines the likelihood of biotransformation reactions, and subsequent metabolite identification, within an automated processing routine.READ MORE
Bioluminescent Assay for GTPases Allows Measurement of GTPase, GAP and GEF ActivitiesPoster
We have developed a homogenous bioluminescent assay (GTPase-Glo) system to analyze these proteins in a simple, convenient “add-mix-read” format.READ MORE
NanoBRET™ Assays for Monitoring Protein Interactions in Living CellsPoster
NanoBRET PPI System is composed of two components.
NanoBRET offers improved S:B over other BRET assays.
NanoBRET provides sensitive live-cell method to study protein interactions.