"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
Poster Apr 01, 2011
David Obermayer, Bernhard Gutmann, Toma N. Glasnov, Tahseen Razzaq, Markus Damm and C. Oliver Kappe
According to the Arrhenius law a further increase of reaction temperatures (e.g. moving from 150 to 250°C) using a suitable reactor environment (e.g. stainless steel) leads to even shorter reaction times.
Working in a high-temperature/high-pressure continuous flow regime, many reactions requiring unusually harsh, exotic or extremely dangerous reaction conditions or the use of supercritical solvents are easily accessed and safely controlled in the microreactor environment.
A recent example of a two-step synthesis in stainless steel equipment is the synthesis of the pesticide Boscalid (BASF) in a Suzuki-Miyaura cross coupling - hydrogenation sequence.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
A luminescent solar concentrator-based photomicroreactor for energy efficient continuous-flow photocatalysisPoster
The Luminescent Solar ConcentratorPhotomicroreactor
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.