Sub-classification of Colorectal Cancer Using Surface Antigen Antibody Microarray and Fluorescence Multiplexing
Poster Nov 29, 2010
Jerry Zhou, Larissa Belov, Pauline Huang, Joo-Shik Shin, Michael J. Solomon, Pierre Chapuis, Les Bokey, Charles Chan and Richard I. Christopherson
Colorectal cancer (CRC) is the second most frequent cause of cancer deaths in Australia. Even after resection up to 50% of patients relapse. In an attempt to prevent recurrences chemotherapy is administered to high risk patients. However, as few as 10-20% patients genuinely benefit because the clinical course for individuals with CRC remains difficult to predict, largely due to prognostically heterogeneous groups within same-stage tumour categories.
Cancer specific biomarkers have played crucial roles in cancer characterisation and prediction. Surface molecules (also known as CD antigens) make ideal biomarkers, as their expression often evolves with tumour progression or interactions with other cell types, such as tumour infiltrating lymphocytes(TILs) and tumour associated macrophages (TAMs).
Optimized Workflow for Single Cell Copy Number Profiling Using High Resolution Oligo CGH ArraysPoster
Here we describe GenetiSure Pre-Screen, a same day, cost-effective, analysis workflow that combines whole genome amplification (WGA) with copy number (CN) profiling using high-resolution oligo CGH microarrays.READ MORE
Preparation of Photonic Biosensors by Inkjet Printing TechnologyPoster
In order to enable local functionalization of label-free optical waveguide biosensors in a cost effective mass-fabrication compatible manner, we investigate surface modification employing inkjet printing of functional polymers and UV-curable benzophenone dextran.READ MORE
Microfluidic Extrusion of Cell-laden Hydrogel Fibers for 3D-BioprintingPoster
An overview on how the incorporation of microfluidic platforms in 3D-bioprinters can open new routes in the creation of heterogeneous, tissue-specific bio-constructs and in the high-throughput screening of bioinks compositions for regenerative medicine and in vitro tissue modeling.READ MORE