TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
Poster Dec 15, 2014
Benjamin Otto1,2, Kristin Klätschke2, Thomas Streichert3, Christoph Wagener2, Genrich Tolstonog4
Identification and prediction of breast cancer subtypes is a wide and highly investigated research field. Many research groups have identified and reported subtype specific signatures. Common to many of these signatures is the supervised approach where specific phenotype associated features are provided as input. We identified TFAP2B in an unsupervised approach and show that the expression correlates with two distinct subgroups of luminal breast cancer which are not identical with Luminal A/B subgrouping. Though several publications describe the association of AP-2α and AP-2γ with breast cancer, AP-2β ist still hardly investigated in the context of breast cancer. Here we investigated the TFAP2B correlations and show that TFAP2B is associated with the WNT/ß-catenin signaling pathway.
Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?Poster
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
T-helper cell phenotype expression in cutaneous lesions of angioimmunoblastic T-cell lymphomaPoster
Angioimmunoblastic T-cell lymphoma (AITL) is a common type of peripheral T-cell lymphoma. AITL can be missed until lymphadenopathy develops in patients initially presenting with skin lesions, as skin biopsy may lack conclusive findings. Our case highlights the extranodal presentation of AITL with cutaneous lesions displaying the TFH phenotype.READ MORE
Novel Role of the Innate Immune DNA Sensor IFI16 (Interferon Gamma Inducible Protein 16) as a Major Epigenetic Modulator During KSHV Infection and Lytic ReactivationPoster
Studies have shown that IFI16 acts as an antiviral restriction factor against a number of DNA viruses, by inhibiting viral replication or transcription through epigenetic modifications. However, till date, no specific epigenetic function of IFI16 has been identified. Here, we have discovered that IFI16 recruits two histone methyltransferases on the KSHV episome leading to altered Histone H3K9 methylation, thus regulating its lifecycle.READ MORE