TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
Poster Dec 15, 2014
Benjamin Otto1,2, Kristin Klätschke2, Thomas Streichert3, Christoph Wagener2, Genrich Tolstonog4
Identification and prediction of breast cancer subtypes is a wide and highly investigated research field. Many research groups have identified and reported subtype specific signatures. Common to many of these signatures is the supervised approach where specific phenotype associated features are provided as input. We identified TFAP2B in an unsupervised approach and show that the expression correlates with two distinct subgroups of luminal breast cancer which are not identical with Luminal A/B subgrouping. Though several publications describe the association of AP-2α and AP-2γ with breast cancer, AP-2β ist still hardly investigated in the context of breast cancer. Here we investigated the TFAP2B correlations and show that TFAP2B is associated with the WNT/ß-catenin signaling pathway.
For circulating cell free DNA (ccfDNA) to be used in cancer research successfully, workflow standardization is essential. Access this poster to discover tips on optimal workflow control, how to yield smaller ccfDNA fragments and the differences in quantification and qualification of ccfDNA.READ MORE