The Challenges of Relieving Cancer Pain: A Literature Review
Poster May 07, 2013
The management of pain has long challenged both oncologists and physicians in general. Pain relief is widely regarded as a priority of oncological care, not only due to its ongoing frequency but also to the detriment it causes to patients’ quality of life and the tendency towards under--‐treatment of cancer pain, especially in the palliative seOng. 30%–85% of cancer patients experiencing pain during the course of the illness, with up to 78% experiencing severe pain.
We show that network analysis of co-localized ions from mass spectrometry imaging data provides a detailed chemo-spatial insight into the metabolic heterogeneity of tumors. Furthermore, module preservation analysis between colorectal cancer patients with and without metastatic recurrence suggests hypotheses on the nature of the different local metabolic pathways.READ MORE
Angioimmunoblastic T-cell lymphoma (AITL) is a common type of peripheral T-cell lymphoma. AITL can be missed until lymphadenopathy develops in patients initially presenting with skin lesions, as skin biopsy may lack conclusive findings. Our case highlights the extranodal presentation of AITL with cutaneous lesions displaying the TFH phenotype.READ MORE
Studies have shown that IFI16 acts as an antiviral restriction factor against a number of DNA viruses, by inhibiting viral replication or transcription through epigenetic modifications. However, till date, no specific epigenetic function of IFI16 has been identified. Here, we have discovered that IFI16 recruits two histone methyltransferases on the KSHV episome leading to altered Histone H3K9 methylation, thus regulating its lifecycle.READ MORE