The Mesenchymal Stem Cells Bioengineered Tissue Using Cobalt-60 Radiation
Poster Feb 16, 2012
Mosca, RC., Isaac, C., Mathor, MB
Here scientists propose an experimental model where the replenishment of the depleted stem cell compartment of human skin may be explored using a dermal epidermal equivalent system, composed by 50 Gy irradiated extracellular collagen matrix, adipocytes derived mesenchymal stem cells (ADSCs) and normal keratinocytes.
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that regulate the expression of phase I (cytochrome P450s), phase II metabolizing enzymes and transporter genes in response to xenobiotics, including prescription drugs.READ MORE
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE