The Role of microRNAs in Memory Consolidation in Lymnaea
Poster Nov 01, 2015
György Kemenes1, Dimitris Vavoulis2, Sergei Korneev1
After single-trial classical conditioning there are well-defined time windows of activation of and requirement for key ‘conventional’ molecular players in the different phases of the consolidation of longterm memory (LTM) in Lymnaea. Two important related discoveries we have made recently are:
i) late LTM (24h post-training) requires transcription at 6h post-training
ii) at 6h post-training, there is ongoing phosphorylation of CREB1 and increased acetylation of H3, both of which can be measured in the ‘learning ganglia’ as well as in single identified neurons known to be involved in learning
However, the requirement for new protein synthesis for LTM only lasts for up to 1h after conditioning. Together, these findings gave rise to the hypothesis that newly transcribed non-coding RNAs (e.g., miRNAs) are involved in the early as well as intermediate-term phase of memory consolidation. We tested this hypothesis by investigating the temporal dynamics of the post-training expression of miRNAs in the ‘learning ganglia’ of Lymnaea.
Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic reviewPoster
This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.
Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?Poster
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
Regulatory T-Cells (Tregs) Within Bone Marrow-Derived Stem Cells (BMSCs) Actively Confer Immunomodulatory and Neuroprotective Effects Against StrokePoster
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE
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