The Synergy™ 2, A Novel Approach to Microplate Multi- Detection for HTS and Drug Discovery
Poster Feb 01, 2007
Paul Held and Xavier Amouretti
The Synergy™ 2 is a new type of reader that provides research laboratories performances usually found on high-end HTS instrumentation, while delivering flexibility and efficient cost-control to screening laboratories. The Synergy 2 utilizes multiple optics to provide performance regardless of the detection technology. Absorbance measurements use a xenon lamp with a monochromator for wavelength selection from 200 nm to 999 nm. Fluorescence measurements are made using either a tungsten-halogen or a xenon-flash lamp with filters and dichroic mirrors and a PMT for detection.
Fluorescence polarization is accomplished with polarizing filters in conjunction with dichroic mirrors. For time-resolved fluorescence measurements, the Synergy 2 integrates a high-energy xenon-flash lamp with excitation and emission filters and PMT detector. Luminescence measurements are accomplished by using a liquid-filled light guide. The Synergy 2 is capable of reading any plate format up to 1536 wells, is robotic compatible and provides temperature control and shaking. Reagent injectors are also available.