Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice
Poster Jul 13, 2016
Charles Evans1, 2, Rhian Thomas1, Emma Kidd1, Mark Good2
We have developed a novel monoclonal antibody, 2B3, which targets APP at the β- secretase cleavage site, inhibiting Aβ production by steric hindrance.
The PDAPP mouse model of AD overexpresses a familial APP mutation is reported to show an age-dependent rise in levels of Aβ and cognitive deficits.
Aβ has been observed to increase NMDA receptor phosphorylation leading to excitotoxicity and cognitive impairment in hAPP mouse models of AD.