Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice
Poster Jul 13, 2016
Charles Evans1, 2, Rhian Thomas1, Emma Kidd1, Mark Good2
We have developed a novel monoclonal antibody, 2B3, which targets APP at the β- secretase cleavage site, inhibiting Aβ production by steric hindrance.
The PDAPP mouse model of AD overexpresses a familial APP mutation is reported to show an age-dependent rise in levels of Aβ and cognitive deficits.
Aβ has been observed to increase NMDA receptor phosphorylation leading to excitotoxicity and cognitive impairment in hAPP mouse models of AD.
Histone Deacetylase 6 (HDAC6) As A Therapeutic Target in Chronic Lymphocytic LeukemiaPoster
This study investigates the role of histone deacetylase 6 (HDAC6) in chronic lymphocytic leukemia and establishes it as a novel therapeutic target for the treatment of this disease.READ MORE
An Emerging Phenotype of Partial RAG 1/2 Deficiency Among Young Children with Autoimmunity and Viral InfectionsPoster
We describe the natural history of a cohort of 12 patients with confirmed partial RAG1/2 mutations and autoimmunity at a young age. We were seeking the link between viral infections and autoimmunity and tested candidate biomarkers that may reflect the underlying RAG1/2 protein deficiency.READ MORE
Improved T Cell Activation Bioassays for Development of Bispecific Antibodies and Engineered T Cell ImmunotherapiesPoster
Here we describe a platform of T cell activation bioassays for the development of CD3 bispecific antibodies and engineered T cell immunotherapies.READ MORE
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World Advanced Therapies & Regenerative Medicine Congress
May 16 - May 18, 2018