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Poster

Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice

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Poster

Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice

We have developed a novel monoclonal antibody, 2B3, which targets APP at the β- secretase cleavage site, inhibiting Aβ production by steric hindrance.

The PDAPP mouse model of AD overexpresses a familial APP mutation is reported to show an age-dependent rise in levels of Aβ and cognitive deficits.

Aβ has been observed to increase NMDA receptor phosphorylation leading to excitotoxicity and cognitive impairment in hAPP mouse models of AD.
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