Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice
Poster Jul 13, 2016
Charles Evans1, 2, Rhian Thomas1, Emma Kidd1, Mark Good2
We have developed a novel monoclonal antibody, 2B3, which targets APP at the β- secretase cleavage site, inhibiting Aβ production by steric hindrance.
The PDAPP mouse model of AD overexpresses a familial APP mutation is reported to show an age-dependent rise in levels of Aβ and cognitive deficits.
Aβ has been observed to increase NMDA receptor phosphorylation leading to excitotoxicity and cognitive impairment in hAPP mouse models of AD.
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Human papillomavirus (HPV) vaccine rates continue to be low in the United States. Young women ages 18-26 years are eligible for catch-up vaccination but previous research shows that relationships status and percieved risk may be barriers to HPV vaccination. The purpose of this quantitative study was to assess the association between relationship status and perceived risk for HPV among young adult women.READ MORE