Transcription Factors to Classify Tumor Types and Subtypes
Poster Dec 12, 2014
Benjamin Otto 1,2, Kristin Klätschke 2, Thomas Streichert 3, Christoph Wagener 2, Genrich Tolstonog 4
Awareness of the role in tumor biology of epigenetics and transcription regulatory mechanisms, such as miRNAs, is increasing. We assume that transcription factors play a crucial role in that context, such that they might be capable of discriminating different tumor classes and yet unknown subgroups. Our approach aims at unsupervised identification of a) sample subsets within a dataset and b) the TFs associated with these subsets. The results show, that an unsupervised selection of TFs can clearly distinguish between the classic breast cancer subtypes and different tumor types such as breast, colon, kidney or prostata cancer. Therefore we assume that the method might help in future to identify new markers suitable for diagnosis of specific treatment related phenotypes or detection of tissues of origin.
Inhibition of The Auto-inflammation Suppressor Protein ISG15 Triggers Preeclampsia by Blocking Trophoblast Migration and InvasionPoster
In summary, ISG15 expression levels are crucial for trophoblast morphology and function (migration/invasion). By blocking trophoblast invasion, reduced ISG15 levels could contribute to impaired spiral artery transformation that reduces utero-placental blood flow in preeclampsia. Thus, agents inducing ISG15 expression are likely to be therapeutic in preeclampsia.
An Emerging Phenotype of Partial RAG 1/2 Deficiency Among Young Children with Autoimmunity and Viral InfectionsPoster
We describe the natural history of a cohort of 12 patients with confirmed partial RAG1/2 mutations and autoimmunity at a young age. We were seeking the link between viral infections and autoimmunity and tested candidate biomarkers that may reflect the underlying RAG1/2 protein deficiency.READ MORE
Severe Combined Immunodeficiency (SCID) caused by thymic aplasia due to a mutation in TBX1Poster
We report one of the first cases of TBX1 haploinsufficiency causing complete thymic aplasia and SCID.READ MORE