Transfecting Small Molecules, Peptides
Poster Nov 19, 2010
Van Q., Atze K., Litzenberger D., Ackerstaff J.T., Strübing Y., Yolcu D., Franke S.,Mobbs K.J. and Kazinski M.
The Nucleofector® Technology enables efficient and reproducible transfection of primary cells and cell lines at throughputs of up to 96 samples per run.
Nucleofection® now extends its range of application to deliver small molecules substrates and protein substrates such as peptides, proteins and antibodyconjugates.
The Nucleofector 96-well Shuttle® System combines the proven advantages of Nucleofection with the flexible throughput capacity to enable cell-based screening approaches using RNAi or peptide libraries, early ADME-Tox applications using small molecules, or pathway validation using inhibitory peptides or antibodies.
The delivery of small molecules, peptides and antibodies is presented, demonstrating the capabilities of the Nucleofector Technology and its potential to enhance standard applications in pharmaceutical research and drug discovery.
A new method for generating arrayed RNAi screening tools for any organismPoster
RNA interference (RNAi) using small interfering RNAs (siRNAs) is an important technology for down-regulation of gene expression and a powerful tool to study cellular processes and pathways. Previously, large collections of siRNAs were available only for traditional experimental model systems, such as human and mouse, and predominantly provided as chemically synthesized libraries.READ MORE
Bioluminescent Kinase Profiling Systems For Characterizing Small Molecule Kinase InhibitorsPoster
In order to profile compounds against a broad panel of kinases, in-house profiling requires rigorous kinase assay development.READ MORE
Pyroptosis Detection via Multiplexing Cell Death and Bioluminescent Caspase-1 Activity AssessmentsPoster
Researchers developed a convenient method to confirm pyroptosis. Inflammasome activation triggers rapid pyroptosis. Preventing pyroptosis may shift form of cell deathREAD MORE
Comments | 0 ADD COMMENT
9th International Conference on Mass Spectrometry and Chromatography
Sep 21 - Sep 22, 2018