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Use of Nanolitre Pipetting in Hit-to-Lead Optimisation
Poster

Use of Nanolitre Pipetting in Hit-to-Lead Optimisation

Use of Nanolitre Pipetting in Hit-to-Lead Optimisation
Poster

Use of Nanolitre Pipetting in Hit-to-Lead Optimisation

Abstract
Assay-ready plates are becoming key to maximizing throughput for many HTS departments. These plates contain test compounds prepared from library stocks ahead of time at the correct concentrations. DMSO is routinely used for compound dissolution, but its presence at concentrations above 1% can markedly affect assay performance. Thus, accurate nanolitre quantities of DMSO-based stock solution are required to keep concentrations low when preparing assay-ready plates. Liquid handlers using disposable tips, such as TTP LabTech's mosquito®, eliminate cross-contamination. Non-disposable pipetting heads can offer high throughputs, but require very stringent wash steps to avoid problems when transferring some compounds
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