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Using StepScan DSC to Measure the Amorphicity of Spray-Dried Lactose Samples

Using StepScan DSC to Measure the Amorphicity of Spray-Dried Lactose Samples content piece image

Abstract

The effect of alternating the parameters of the heating program on the signal of StepScan DSC was studied. In this study samples were amorphous spray-dried lactose. The heating program includes two different states. In the first state, the heating state, sample is heated small temperature increments by some known heating rate. The second state, the isothermal state, includes a short isothermal time interval in which the sample reaches a thermal equilibrium.