Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay

Poster   Feb 16, 2012

 
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
 
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Brad Larson, Tracy Worzella, Rich Moravec, Neal Cosby, Frank Fan, Teresa Surowy and Peter Banks

 
 

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

 
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Knockout of microRNAs Using the CRISPR-Cas9 System with Paired Synthetic crRNAs

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We utilized paired synthetic crRNAs coupled with our synthetic tracrRNA in cells transduced with lentiviral Cas9 to perform a functional knockout on hsa-miR-221. This three-part system (crRNA, tracrRNA and Cas9) has demonstrated efficient gene editing when used with only one guide RNA, but the goal was to use two crRNAs to remove the entire stem-loop.

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Using Remote Sensing Methodologies to Combat Schistosomiasis in Northern Senegal

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Schistosomiasis is associated with poverty, a lack of clean water and sanitation and is is transmitted through snail vector. Remote sensing methodologies were used to identify types of vegetation that are significantly associated with snail presence as previous studies had shown that removal of certain aquatic vegetation decreased the prevalence of schistosomiasis in nearby villages.

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New Biotransformation Prediction Engine Integrated into a Metabolite Identification Solution

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Here we present a new prediction algorithm that determines the likelihood of biotransformation reactions, and subsequent metabolite identification, within an automated processing routine.

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