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Epitome Launches Ti-Tyr™ Profiling Chips for Measurement of Multiple Cellular Events

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Epitome Biosystems announced the commercial launch of its Ti-Tyr™ Phosphorylation Profiling Chip, providing researchers with substantially increased capabilities for measuring cellular activities in their drug discovery and development efforts.

According to Epitome, the Ti-Tyr™ Chips enable specific, cell-based measurements of biological function to be made in a multiplexed format, increasing the amount of relevant data generated per sample.

Ti-Tyr™ Chips incorporate Epitome’s proprietary EpiTag™ technology and are one in a series of products from Epitome providing valuable information on the underlying basis of disease and drug responses.

“All drugs trigger some form of cellular response across a network of signals,” said Neal Gordon, Ph.D., President, Epitome Biosystems.

“By making simultaneous activity measurements across many cell targets, our products, such as the Ti-Tyr™ Profiling Chip, are paving the way for more informed decision making in drug development and in assessing patient treatment options. Powerful approaches for delivering comprehensive and biologically significant information about cell states are something the market has been demanding for a long time and will drive a paradigm shift in medical research,” said Gordon.

The Ti-Tyr™ Chip is high sample throughput approach for assessing cell activity states by profiling tyrosine phosphorylation. Cell activity is a highly regulated process and many diseases are caused by disruptions or alterations in cell signaling networks.

Ti-Tyr™ Chips measure quantitative phosphorylation changes with picomolar sensitivity, across a range of signaling pathways and cellular phenotypes. These measurements are an important foundation for drug discovery efforts focused on targeting kinases, particularly in oncology, diabetes and immune disorders.

First generation Ti-Tyr™ Profiling Chips are being offered as an early access product program beginning with sample analysis performed at Epitome with subsequent customized technology transfer for in-house use.

In addition, Epitome offers Q-SONAR™, a complementary mass spectrometry-based phosphorylation profiling discovery service. Q-SONAR™ delivers reproducible phosphorylation profiles – allowing researchers to see the big picture of network responses and allowing them to focus on nodes or targets of interest.