Latest Affymetrix Microarray Offers New Users a Cost-effective and Easy-to-use Alternative for Gene-level Expression Profiling
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Affymetrix Inc. has announced the full commercial launch of the GeneChip® Human Gene 1.0 ST Array, the latest addition to its whole-transcript assay-based gene expression product family.
The microarray measures the overall expression of all transcripts derived from a gene, not just the 3’ end of a gene. As a result, the Human Gene 1.0 ST Array delivers a more complete and accurate view of a gene’s total transcription activity compared to traditional expression array designs.
The Human Gene 1.0 ST Array is a cost-effective gene expression profiling option for new microarray users. Its affordable price and simplified workflow will enable more scientists to incorporate microarray technology in their research more often.
Researchers will also be able to perform larger expression studies with additional replicates to gain a more accurate picture of gene activity. The latest Affymetrix product complements the more comprehensive Human Exon 1.0 ST Array, which offers both gene-level expression profiling and alternative splicing analysis in a single experiment.
“The new Human Gene 1.0 ST Array offers the latest available content at an attractive price point, making it an ideal solution for researchers with restricted budgets who were not able to work with Affymetrix technology in the past,” said Shawn Levy, Ph.D., assistant professor of biomedical informatics and director of the Vanderbilt Microarray Shared Resource.
“With the gene and exon arrays on the same WT assay platform, Affymetrix provides a logical product progression that enables customers to gain an understanding of the critical roles that gene expression or alternative splicing play in biology.“
In the Human Gene 1.0 ST Array design, each of the 28,869 genes is represented by a set of approximately 26 probes. This simplified design strategy provides one value from one probe set for each gene, yielding a more accurate representation of all of the transcription activities for each gene of interest than traditional expression array designs.
Affymetrix Expression Console™ Software offers additional tools to further simplify the analysis workflow, making it as easy to interpret gene-level expression on Human Gene 1.0 ST Arrays as 3’-based expression microarrays.
“Between the traditional 3’ U133 Array, the new-generation Human Exon 1.0 ST Array and now the Human Gene 1.0 ST Array, Affymetrix has the most complete portfolio of gene expression products to meet the growing and diverging customer demands,” said Sean George, vice president of the academic business unit at Affymetrix.
“The new Human Gene 1.0 ST Array complements the Human Exon 1.0 ST Array, offering an additional choice for new microarray users on the gold-standard microarray platform at a very affordable price. This product is a direct result of Affymetrix’ continued innovation and dedication to making larger-scale genomic studies more economical.”
The Affymetrix Human Gene 1.0 ST Array utilizes the same GeneChip technology that has been the industry standard in microarray research for the past decade.
