Metabolomics and Proteoform Profiling for Life-Science and Translational Research

Bruker introduces its third-generation metabolomics research and validation solution, MetaboScape® 3.0, which has powerful new features essential for discovery metabolomics, including support for direct-injection (DI) or MALDI Magnetic Resonance Mass Spectrometry (MRMS) for high-throughput phenomics translational research and validation. Innovations include a novel algorithm called Time-aligned-Region-complete-eXtraction (‘T-ReX’), which automatically extracts all relevant information in sample cohorts in a “region complete” manner. Included in MetaboScape 3.0 are workflows that support evaluating high-throughput, chromatography-free DI-MRMS or MALDI-MRMS data, enabling two powerful extreme mass resolution techniques that enable higher sample throughput for profiling complex metabolic extracts. The speed and high throughput of these MRMS methods yields advantages for validating larger sample cohorts, and enabling larger-scale longitudinal studies.

Professor Philippe Schmitt-Kopplin at the Helmholtz Zentrum for Analytical BioGeoChemistry in Munich, Germany, elaborated: “We set up new discovery approaches to describe the compositional space of any complex system in biology and geochemistry. The eXtreme Resolution of Magnetic Resonance Mass Spectrometry (MRMS) enables us to address next-generation “metabotyping”, i.e. simultaneous rapid description of hundreds of known and thousands of new metabolites relevant for dynamic biological/chemical processes. MRMS in combination with MetaboScape will also enable other researchers to shed light onto this new and exciting research field of exploring the yet ‘dark metabolome’.”