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New Green Standard for Fast Preparative Chromatography from SFC Instruments

The Sepiatec SFC-50 instrument.

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BUCHI Labortechnik AG has added Sepiatec SFC, its first Supercritical Fluid Chromatography (SFC) systems, to its preparative chromatography portfolio. Thanks to smart system design and substantial reductions in organic solvent use, the Sepiatec SFC line enables a more efficient and eco-friendly purification performance.


“With growing economic and environmental concerns, purification labs are under increasing pressure to work, greener, faster and cheaper,” said Dr. Ruedi Hartmann, Director Business Areas & Vertical Markets at BUCHI Labortechnik. “Many are turning to SFC as an alternative to traditional prep HPLC, mainly due to the use of carbon dioxide as an alternative to organic solvents. SFC can drastically reduce the use of expensive, hazardous, and environmentally harmful mobile phases while still achieving shorter run times and high separation efficiency for many types of compounds.”


The SFC method is demonstrably faster than prep HPLC. This type of chromatography has shorter run times thanks to the low viscosity of supercritical fluids used as mobile phases. High separation efficiency can be readily achieved, allowing for increased loading capacity and fast injection cycle time, speeding up the process even more. Time is also saved due to quicker solvent disposal and recovery.


“As SFC grows in popularity, BUCHI has introduced a new line of SFC instruments with convincing features to encourage beginners and satisfy advanced users,” added Dr. Hartmann. “By combining usability and flexibility in the market’s smallest SFC system, we hope to make SFC accessible to everyone.”


The Sepiatec SFC instruments are designed to make a wide variety of applications possible. With a broad range of pump flow rates, column sizes and lengths, compatibility with UV, ELSD and MS detection, options for stack or multiple injections, fraction collection without limitations on volumes and the possibility to operate the system on the benchtop or in a fume hood, operators are free to customize their system to their needs.


The Sepiatec SFC product line joins BUCHI’s established portfolio of preparative chromatography solutions. Together with systems for flash chromatography & prep HPLC, chromatography columns, cartridges and accessories, BUCHI Labortechnik AG continues to support customers in the pharmaceutical, chemical and biotechnological industries in their efforts to maximize efficiency while achieving highest compound purity.

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