Roche NimbleGen Offers Epigenomic and Transcriptional Regulation Tools with HD2 Arrays and Services
Product News Nov 06, 2008
Roche NimbleGen has expanded its growing line of tools for analyzing the epigenome and genome-wide transcriptional regulation mechanisms by launching HD2 arrays and services for chromatin immunoprecipitation (ChIP-chip).
NimbleGen ChIP-chip HD2 arrays now provide more than a 5-fold increase in probe density per array, which allows for increasing the coverage of key biological features, such as promoters and CpG islands, and decreasing the number of arrays needed to perform whole-genome analysis at high resolution.
ChIP-chip is a powerful technique that allows for the high-resolution mapping of chromatin structure including histone modifications, transcription factor and nucleic acid polymerase binding, nucleosome location, and DNase I hypersensitivity. These various applications enable researchers to determine what regions of the genome are transcriptionally active, which regions are repressed, and what mechanisms regulate these processes.
Unraveling the fundamental epigenomic and genomic regulatory pathways underlying normal cell growth and tissue differentiation, as well as changes in regulatory control associated with disease, is crucial for the development of drugs that target these pathways.
Roche NimbleGen is recognized as the leading platform for ChIP-chip studies and the main array platform used by researchers participating in the ENCODE consortium, a project aimed at characterizing the functional elements of the human genome.