Sigma® Launches ChIP Kit Technology for Epigenetic Research

The Imprint™ ChIP Kit is designed to provide a complete solution for Chromatin Immunoprecipitation, including columns and reagents for DNA purification as well as an integrated protocol for ChIP DNA amplification with the GenomePlex® Whole Genome Amplification Kit. This flexible format allows for immunoprecipitation and purification of DNA from mammalian cells or tissue in a convenient microwell format.

According to Sigma-Aldrich, the ChIP is technology that enables scientists to investigate complex DNA-protein interactions in vivo, potentially increasing the speed and accuracy of disease research and drug discovery.

The Imprint™ ChIP Kit provides researchers with rapid and accurate results, enabling high-throughput, same-day downstream analyses via quantitative PCR, MS-PCR, and DNA sequencing as well as DNA microarray. With the shortest protocol time and highest throughput capabilities on the market, the Imprint™ ChIP Kit, offers significant time and cost savings to epigenetic researchers.

"Sigma's Imprint™ ChIP Kit incorporates all of the requirements for Chromatin Immunoprecipitation procedures," said Tim Fleming, Director of Global Commercial Marketing for Sigma-Aldrich Life Science. "These integrated tools will help researchers better understand complex protein networks and expedite epigenetic research and development."

The Imprint™ ChIP Kit complements Sigma Life Science's robust product line to support the epigenetic workflow, including the Imprint™ DNA Modification Kit as well as products for DNA purification, qPCR, sequencing and post-reaction clean-up. The Imprint™ ChIP Kit is based on Chromatin Immunoprecipitation (ChIP) technology licensed from Epigentek Group.

"This arrangement reinforces Epigentek's leading position in the epigenetic arena," said Adam Li, Chief Scientific Officer for Epigentek. "We share Sigma's commitment to developing the next generation of research tools for epigenetic research."