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Sigma-Aldrich Introduces Panorama™ Signal Transduction Protein Array

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Sigma-Aldrich has announced the latest addition to its functional protein array product line, the Panorama™ Human Signal Transduction Protein Array.

Developed in conjunction with Procognia Ltd, UK, and licensed exclusively through Sigma-Aldrich, the Signal Transduction array contains 259 full-length proteins that are involved in key cellular processes including proliferation, differentiation and apoptosis.

This array employs a unique fusion tag that has been shown to confer protein functionality and that also serves to select, tether and uniformly orientate proteins on a streptavidin-coated glass slide.

This technology is designed to offer the advantage of allowing proteins to behave in a sterically unencumbered manner, thereby increasing the potential for acquiring data that is more closely representative of native physiological states.

Signal transduction describes cellular response to external or internal stimuli and often results in fundamental cellular changes such as regulating gene expression or controlling cell proliferation.

"With a multiplex assay format, the researcher is empowered to recognize signaling transduction in disease states and to characterize specific proteins involved in the intricate cascade of events that follow," said Richard Pembrey, Market Segment Manager, Functional Proteomics.

"With the first commercially-available array specifically targeting signal transduction, researchers can study the function of key protein families by performing parallel assays for selectivity with other proteins, antibodies, peptides, kinases and drug candidates."