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ACQUITY™ Premier UPLC™ System

ACQUITY™ Premier UPLC™ System: The next evolution in separation science is here.
Maximizing the sensitivity, repeatability, and robustness of your LC and LC-MS applications is critical. The ACQUITY Premier System is the next evolution of the Performance LC System which include the ACQUITY UPLC H-Class PLUS and ACQUITY UPLC I-Class PLUS Systems. Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY UPLC PLUS Series, the ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control.
The ACQUITY Premier System features MaxPeak High Performance Surfaces (HPS) Technology, which offers improvements in separation and detection of metal-sensitive analytes, enabling you to minimize the risk of undetected analytes – for increased efficiency and confidence in your results.
Minimize risk of undetected analytes with MaxPeak High Performance Surfaces (HPS) Technology. Decrease time-to-result and increase overall efficiency by eliminating time-consuming system and column passivation. Improve peak shape and reproducibility for the most challenging metal-sensitive compounds. Achieve high-precision injections with direct inject sampling. Reduce time on method development. Utilize multi-software platform support options with Empower, MassLynx, and UNIFI. Achieve sample injection versatility, depending upon your application, with the flow-through needle and fixed loop injector options.
Tough metal-sensitive compounds? Not anymore. Non-specific adsorption of metal-sensitive compounds is an unpredictable challenge, leading to long system passivation times, chromatography with large RSDs, and broad peaks that can be a challenge to detect. The ACQUITY Premier System is built with proven ACQUITY technology, which offers true UPLC performance, ultra-low dispersion, and high resolution. Designed with MaxPeak HPS Technology, the ACQUITY Premier System improves peak shape and reproducibility for the most challenging metal-sensitive compounds.
Boost method efficiency with UPLC technology. Take your methods to the next performance level by leveraging the benefits of Ultra Performance Liquid Chromatography (UPLC) technology to improve your existing HPLC methods. By scaling your methods to UPLC, your laboratory will benefit from the combination of increased resolution, sensitivity, and speed that comes with modern small-particle chemistries. Along with fast UPLC analysis times, the ACQUITY Premier System reduces the need for system passivation to optimize assays for metal-sensitive compounds. Take your assays to the next level of efficiency, not only with faster analysis times, but also reduced system downtime, decreased reagent costs, and, ultimately, improved lab productivity.
The ACQUITY Premier System minimizes metal-sensitive analyte loss, improving recovery and limits of detection. Couple the ACQUITY Premier System with a Waters mass spectrometer to confidently identify and quantify unknown compounds in complex samples and confirm trace components at the lowest possible levels.
Reproducible results with a reliable partner. The ACQUITY Premier System and ACQUITY Premier Columns are holistically designed to reduce analyte losses and improve repeatability for a diversity of metal-sensitive analytes that interact with metal surfaces in conventional LC technology. Waters also delivers world-renowned services and support, tailored to optimize your laboratory productivity while addressing budget realities. Our offerings help you maintain peak system performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.


Product Specifications
Maximum operating pressure 15,000 psi
pH range 1 to 12.5
Operating flow rate range 0.001 to 2.000 mL/min
Injection type Flow-Through Needle, Fixed Loop
Sample flow path Inert (MaxPeak HPS Technology)
Sample carryover ≤0.002%
Sample compartment 4 to 40 C
Pump options Binary, Quaternary
Solvent conditioning Active pre-heating as standard
Column tracking eCord Technology column information management tracks and archives column usage
About Waters Corporation
Waters Corporation, a global leader in analytical instruments and software, has pioneered chromatography, mass spectrometry and thermal analysis innovations serving the life, materials, food and environmental sciences for more than 60 years. With more than 7,800 employees worldwide, Waters Corporation operates directly in 35 countries, including 14 manufacturing facilities, and with products available in more than 100 countries.
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