ANGPT2/TIE2: Attractive Targets for Improved Anti-angiogenic Cancer Therapy

Angiopoietin-2 (ANGPT2) is a ligand of the receptor tyrosine kinase TIE2 (TEK). In conjunction with vascular endothelial growth factor (VEGF), ANGPT2-TIE2 signaling induces vascular sprouting. Inhibition of ANGPT2 shows promising results in preventing tumor angiogenesis, tumor growth, and metastasis in preclinical models, making it an attractive candidate to target in cancer.

ANGPT2 is highly upregulated at the early stages of tumor progression to drive neovessel formation. Conventional anti-VEGF therapies primarily target immature blood vessels in tumors. The combinational targeting of both ANGPT2 and VEGF pathways is now expected to improve clinical efficacy by expanding the target vessel population. Sino Biological has developed high-quality reagents to support the study of the ANGPT2/TIE2 signaling.

ANGPT2/TIE2 Pathway Proteins
ANGPT2/TIE2 Pathway Antibodies