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ELEVECTA™ Producer Cell Line: For Stable, Inducible Adeno-Associated Virus Production
ELEVECTA™ producer cell line is a stable line for inducible AAV production. It is a true producer cell line that has Rep, Helper, Cap, and gene of interest (GOI) stably integrated into the host cell’s genome, and it requires only a single induction step to initiate AAV production.
ELEVECTA producer cell line key benefits:
- Simplified manufacturing process: Replace multi-step transfection with single-step production by adding an induction reagent.
- Scalability: Scale up seamlessly to achieve large quantities of AAV material.
- Reproducibility: Benefit from a monoclonal cell line from which AAV is produced in an identical manner, enabling consistency from batch to batch.
- Reduced COGS: Skip the need for transfection reagent and any plasmid DNA, which are the most expensive raw materials in classical AAV transient transfection.
Product Specifications
Alpha cell line
HEK293 or cell line derived from human amniocytes cells (Cytiva CAP cell line )
AAV serotypes
Common or engineered
Packaging capacity
~ 4.7 kb
Cell banking
Non-GMP research cell bank (RCB)
Upstream process development
Small scale to large scale from FastTrak™ services (optional)
Stability testing
Included
About Cytiva
Cytiva is a global life sciences leader dedicated to helping customers discover and commercialize the next generation of therapeutics. Together, we bring dedicated technical expertise and a broad portfolio of tools and technologies that enable the development, manufacture, and delivery of transformative medicines to patients.
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