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Results for 'cryo-em'

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Cryo-EM Provides the Structural Blueprint for Protein Nanomachines content piece image
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Cryo-EM Provides the Structural Blueprint for Protein Nanomachines

We spoke to Cristina Paulino, Assistant Professor in high-resolution cryo-electron microscopy (cryo-EM) at the University of Groningen, to learn about the role cryo-EM plays in her group's work in the study of membrane protein structure and function.
Why Automation Has a Major Role to Play in the Future of Cryo-EM  content piece image
Article

Why Automation Has a Major Role to Play in the Future of Cryo-EM

Cryogenic electron microscopy (cryo-EM) is an indispensable technique for structural biologists. But this wasn’t always the case. We spoke to Bridget Carragher, Co-Director of the Simons Electron Microscopy Center to discover how automation has improved cryo-EM.
Cryo-EM and CX-MS: The Power Couple of Proteomics content piece image
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Cryo-EM and CX-MS: The Power Couple of Proteomics

An ambitious new workflow has married two cutting-edge proteomic analysis techniques to improve imaging of large protein assemblies. The combination of electron cryo-microscopy (cryo-EM) and cross-linking coupled mass spectrometry (CX-MS) allows deeper interrogation of protein structures to a level of detail that the techniques are incapable of obtaining on their own.
The Give and Take Relationship of XL-MS and Cryo-EM content piece image
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The Give and Take Relationship of XL-MS and Cryo-EM

Structural biology has recently observed the marrying of two remarkably complimentary techniques for the study of protein structure and interaction: cross-linking mass spectrometry (XL-MS) and the Nobel prize winning cryogenic electron microscopy (cryo-EM).
Taking a Closer Look at Microbial-Environmental Interactions With Cryo-EM content piece image
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Taking a Closer Look at Microbial-Environmental Interactions With Cryo-EM

No microbe is an island. Understanding how they interact with each other and their surrounding environment is important to harness their beneficial properties and combat harmful behavior. We spoke to Professor Ariane Briegel about the important role of cryo-EM in these studies.
How Cryo-EM Structural Insights Accelerate and Improve Drug Discovery content piece image
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How Cryo-EM Structural Insights Accelerate and Improve Drug Discovery

Determining the structure of a target with its ligand is key in guiding the development of new drug molecules. Cryo-EM is transforming drug discovery by helping researchers obtain structural insights into a broad range of otherwise intractable biological targets.
Drawing of neurons in the brain.
Article

Cryo-EM Research Is Changing the Way We Look at Neurodegenerative Diseases

This article takes a look at how cryo-electron microscopy is emerging as a critical tool in the structural analysis of tau filaments and how it is helping to advance tauopathy research.
Cryo-Electron Microscopy: Guiding the Next Generation of Therapeutics With Complex Insights content piece image
Article

Cryo-Electron Microscopy: Guiding the Next Generation of Therapeutics With Complex Insights

This article explores how advances in cryo-EM are promising to bridge the divide between cellular and molecular biology, leading to the development of targeted treatments for diseases such as COVID-19.
Scientist Explains How They Un-picked Pick’s Disease content piece image
Article

Scientist Explains How They Un-picked Pick’s Disease

Scientists use Cryo-EM to solve the structure of the frontotemporal dementia-causing tau protein tangles.
A 3D map and a 3D model of a protein structure generated using cryo EM.
Article

Cryo Electron Microscopy: Principle, Strengths, Limitations and Applications

Cryo electron microscopy (cryo EM) has revolutionized our understanding of the intricate molecular machinery that governs life. In this article, we discuss what cryo EM is, how it works, it's strengths, limitations and applications.
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