Advanced Cell Models – News and Features

Researchers have discovered a key mechanism that makes prostate cancer cells resistant to the latest drugs, solving a long-standing puzzle in tumor biology.

Researchers used CRISPR screening in tumor organoids and mice to identify two genes, Ctnna1 and Bcl2l13, that suppress colorectal cancer metastasis. One limits cell invasion, while the other triggers cell death after detachment.

Researchers have uncovered a mechanism that protects nerve cells from premature cell death, providing the first molecular evidence that ferroptosis can drive neurodegeneration.

Researchers identified a bacterial enzyme that enables Streptococcus pneumoniae to invade heart cells and cause damage, explaining why some pneumonia patients suffer cardiac complications.

Scientists have created a scalable 3D organoid model that captures key features of early limb development, revealing how a specialized signaling center shapes both cell identity and tissue organization.

Researchers have uncovered a specific form of epigenetic aging that leads to the shutdown of key genes in intestinal stem cells.

Discover a simple, automated method of producing many lung organoids at once, open the door for more effective ways to trial lung disease and cancer treatments.

Automated lung organoid production offers scalable, human-based models for testing therapies and accelerating lung disease research.

Using human iPSC-derived kidney organoids, researchers showed that NPHP1 deficiency triggers abnormal Hippo signaling that accelerates fibrosis in nephronophthisis. The model reproduced disease-specific scarring not seen in animals.

Where do the greatest opportunities for collaboration across life sciences disciplines lie today – and what’s needed to unlock them? We asked the experts.