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Advanced Cell Models – Webinars and Online Events

Webinar

The Dash for NASH: How To Succeed in NASH Therapeutic Development

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of metabolic disorders that affects 25% of our global population. 20% of those with NAFLD develop non-alcoholic steatohepatitis (NASH), which can result in cirrhosis and liver cancer.

Despite continued research and development efforts, not one NASH therapeutic agent has made it to market yet. Traditional preclinical tests have repeatedly failed to predict human drug efficacy as they inadequately recreate the complexity and multifaceted nature of this human disease. As a result, NASH is poised to become a global health and economic burden.

Is it time to increase your chances of clinical success with a new human-relevant approach to drug discovery and development?
Webinar

Cell-to-Cell Communication in Cancer

In this webinar, Dr. Holz will discuss the background of cell-to-cell communication, highlighting studies and recent developments in the field as well as exploring the clinical implications of these studies on cancer biology and patient care.
Webinar

Every Breath You Take: Predicting Inhaled Drug ADME Using Lung-on-a-Chip

On-Demand
The administration of drugs via inhalation into the lungs is superior to many other methods of delivery because our lungs provide a large surface area for absorption, access to the whole blood volume and comparatively little metabolic activity. Currently, there are limited in vitro models in which the absorption and permeability of drugs across the lung and into systemic circulation can be precisely measured.

In this webinar, Dr. Emily Richardson will describe novel lung-on-a-chip (LOAC), otherwise known as lung microphysiolological system, models of the alveoli and bronchi which can be used to accurately predict drug pharmacokinetics, allowing for more rapid, precise and cost-effective analysis of compounds.

Webinar

Predictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and Spheroids

On-Demand
To explore how this challenge might be approached, 780 human Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules.
Webinar

Intestinal Organoids and Their Role in Tissue Engineering

On-Demand
This webinar will explore how we can isolate and expand patient-derived intestinal organoids in culture. By combining these organoids with scaffolds, we can generate functional intestinal mucosal grafts which demonstrate a proof-of-concept for subsequent clinical translation and future use in patients.
Webinar

From Dose to Circulation – Determination of Drug Oral Bioavailability Using a Gut–Liver Microphysiological System

On-Demand
In this webinar, Dr. Yassen Abbas will discuss how CN-Bio’s gut–liver MPS can be used for in vitro determination of oral bioavailability.
Webinar

Revealing the Developing Brain With Single-Cell Multiomic Profiling of Human Cerebral Organoids

On-Demand
The powerful combination of stem-cell derived organoids and single-cell multiomics is revolutionizing developmental cell biology.
Webinar

Human Liver Microphysiological System for Studying Acute and Chronic Drug-Induced Liver Toxicity

On-Demand
With safety concerns being the major cause for failures in Phase 1/2 clinical trials, it’s essential to develop more predictive models within preclinical drug discovery to improve data translatability.
Webinar

Liver-on-Chip and In Silico Modeling for Quantitative Drug Metabolism Studies

On-Demand
This webinar will examine the benefits of combining LOAC with in silico modeling to explore clinical PK predictions of specific reference drugs, including investigations into the intrinsic clearance determinations for high metabolically stable compounds and the quantitation of fractions metabolized by specific enzymes.
Webinar

Retinal Organoids as an Emerging Tool for Drug Discovery

On-Demand
Human induced pluripotent stem cell (iPSC)-derived retinal organoids are an emerging tool for the study of retinal development, disease modeling and drug discovery.
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