We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement

Anticancer Therapies – Multimedia

Video

Biomarkers to Predict Aggressive Prostate Cancer

Claire Morgan discusses the need to identify a panel of biomarkers that may distinguish indolent cancer from aggressive metastatic disease when used collectively.
Rapid Detection of Somatic Mutations in Cancer Genes content piece image
Poster

Rapid Detection of Somatic Mutations in Cancer Genes

Rapid higly sensitive detection of tumor gene mutations in DNA derived from FFPE or plasma samples can be achieved with QClamp PCR technology.
Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method content piece image
Poster

Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method

This study demonstrates that the cell culture assay for tumorsphere size was successfully adapted to 384-well plate for a 3D spheroid assay using U-bottom low attachment 384-well and the Celigo Automated Imager for image acquisition and analysis. Moreover, the utilization of an imager provided insight on sphere and cell fate after long term drug treatment.
Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor content piece image
Poster

Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.
Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method content piece image
Poster

Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method

3D Tumorspheroid models for improved predictivity in cancer drug discovery.
Characterization of Antibody-Drug Conjugates by SEC with Combined Light Scattering  content piece image
Poster

Characterization of Antibody-Drug Conjugates by SEC with Combined Light Scattering

Drug Antibody Ratio (DAR) is a critical factor to the effective design of antibody-drug conjugates (ADC). This poster presents a method for DAR determination based on SEC-MALS in conjunction with UV absorption and differential refractive index detection.
Video

Monitoring Dynamic Interactions of Tumor Cells with Tissue and Immune Cells in a Lab-on-a-Chip

Peter Ertl discusses how for the first time, direct cell-to-cell interactions of tumor cells with bead-activated primary T cells were continuously assessed using an effector cell to target cell ratio of 10:1.
Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system content piece image
Poster

Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.
Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor content piece image
Poster

Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor

The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.
Sub-classification of Colorectal Cancer Using Surface Antigen Antibody Microarray and Fluorescence Multiplexing content piece image
Poster

Sub-classification of Colorectal Cancer Using Surface Antigen Antibody Microarray and Fluorescence Multiplexing

Colorectal cancer (CRC) is the second most frequent cause of cancer deaths in Australia. Even after resection up to 50% of patients relapse. In an attempt to prevent recurrences chemotherapy is administered to high risk patients. However, as few as 10-20% patients genuinely benefit because the clinical course for individuals with CRC remains difficult to predict, largely due to prognostically heterogeneous groups within same-stage tumour categories.
Advertisement