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Anticancer Therapies – News and Features

Pancreatic cancer cells (nuclei in blue) growing as a sphere encased in membranes (red).

Could We Make KRAS Inhibitors More Effective Against Pancreatic Cancer?

KRAS inhibitors are showing initial promise in clinical trials, but many tumors quickly develop resistance to the treatment. Now, researchers have discovered a new mechanism of resistance that suggests an opportunity to make the treatment more effective.
Above image shows a metastatic tumor in the left lung of a patient and the bottom image shows no tumor following treatment.

Immunotherapy Approach May Be Effective for Some Metastatic Tumors

Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may effectively treat metastatic solid tumors.
A virus-specific T cell in the vascular system of a liver with chronic hepatitis B virus infection.

Liver Cells Put a “Sleep Timer” On Immune Cells in Chronic Hepatitis B Infection

A team has discovered that cells in blood vessels in the liver start a “sleep timer” that switches off immune cells, and targeting this mechanism could be a starting point for immunotherapies.
Hospital beds on a ward.

Cell-Based Lymphoma Therapy Shows Promise in Trial

CAR-T cell therapy causes tumors to shrink or disappear, but if this CAR-T treatment fails, the median survival time after relapse is about six months. Now, a phase 1 clinical trial has found that a new CAR-T cell therapy significantly improved these patients’ outcomes.
Immune cells attacking a cancer cell.

Researchers Create Novel Cell Type That Kills Cancer Cells in Research Models

Researchers have combined the genetic components of four types of cells to make a powerful new cell type, Co-STAR (Co-stimulatory Synthetic T-cell receptor and Antigen Receptor) cells. These cells were able to produce a sustained anti-tumor response against human cancer cells in laboratory studies.
Gloved hands draw medicine into a syringe from a glass vial.

Liver Tumor Microproteins Could Lead to Cancer Vaccines

A study has identified a group of small molecules that could be key to developing cancer vaccines. These microproteins are very small proteins expressed only by tumor cells and can activate immune cells against the tumor.
Two cytotoxic T cells attack a cancer cell.

Stem Cell-Derived Therapy Shows Early Promise for Resistant Liver Cancer

An innovative new stem cell-derived therapy could be used to better target and treat the most common form of liver cancer.
A person massages their sore wrist.

Tool Predicts Nerve Damage From Cancer Treatment

Many women treated for breast cancer using taxanes, a type of cytostatic drug, often experience side effects in the nervous system. Researchers have now developed a tool that can predict the risk level for each individual.
A person undergoing intravenous therapy

Potential Therapeutic Target Could Boost Pancreatic Cancer Chemotherapy and Reduce Spread

A research team has discovered that nidogen-2 reduces the dense scaffolding tissue within pancreatic tumors, which is a major barrier to treatment and contributes to the cancer’s well-known chemotherapy resistance.
A gloved hand holds a syringe filled with yellow liquid.

World-First CAR T-Cell Therapy for Child With Lupus

CAR T-cell therapy has been used for the first time to treat lupus in a child, restoring the patient's ability to live a normal life.