Cancer Genetics – News and Features

TCGA team describes the discovery of new genetic mutations and other types of DNA alterations with potential implications for the treatment of glioblastoma.

Applied Biosystems announced the development of a sequencing-based molecular tool for the genomic analysis of whole transcriptomes, the vast collection of RNAs transcribed from a genome. This technology provides detailed characterization of expressed protein-encoding genes, identifies many non-coding RNAs, and includes sample multiplexing capability.

The researchers found that the same gene mutations play a significant role in high-risk forms of non-inherited neuroblastoma.

Medulloblastomas are driven by mutation-altered stem/progenitor cells of the normal brain study shows.

A drug-like molecule can be substituted for the cancer gene c-Myc, one of four genes added to adult cells to reprogram them to an embryonic-stem-cell-like state, says Whitehead researchers.

Syngene’s image analysis software is being used by scientists at GUMC to assess molecular mechanisms of novel pro-drugs on breast cancer cells.

A drug created from this newly found molecule would help fight the life-threatening disease while leaving patients’ kidneys intact, researchers say.

The gene, HER2, causes cancer stem cells to multiply and spread, explaining why HER2 has been linked to a more aggressive type of breast cancer.

Researchers found that multiple myeloma cells rely on the activity of a single protein for the activation of a wide range of genes responsible for cell survival and spread.

Study published in the journal Cancer Cell identifies SPINK1 as a new biomarker for prostate cancer.