Cancer Immunology – News and Features

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Personalized Cancer Vaccines Slow Tumor Recurrence in Mice
Using a newly discovered byproduct of dying cancer cells, University of Wisconsin–Madison researchers are developing personalized vaccines that could help keep aggressive tumors from recurring.

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Enabling the Body To Engineer Its Own CAR T Cells
A new approach induces the patient’s body to produce its own CAR-T cells, relying on the same messenger RNA (mRNA) technology that was instrumental for some COVID-19 vaccines.

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Key B-Cell Lymphoma Traits Linked With Greatest Benefit From CAR T-Cell Therapy
In the largest study of its kind, researchers from The University of Texas MD Anderson Cancer Center identified three subgroups of patients with large B-cell lymphoma who have different levels of benefit from CD19 CAR T-Cell Therapy.

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First Use of CAR T-Cell Therapy for Autoimmune Neuropathy
A team of physicians from Bochum are the first to successfully use CAR T-cell therapy to treat two patients with a rare autoimmune disease of the peripheral nervous system.

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Blood Test May Help Detect Liver Transplant Issues Early
Studying the chemical signatures of DNA fragments in the blood could help scientists pinpoint the cause of organ damage post-transplant, without the need for costly imaging studies or invasive biopsy tests.

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FDA Approves Pembrolizumab for Advanced Head and Neck Cancer
Pembrolizumab, an immune checkpoint inhibitor, has been approved by the US Food and Drug Administration for the treatment of patients with resectable locally advanced head and neck squamous cell carcinoma whose tumors express PD-L1.

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New Method Helps Track Immune Cells During Immunotherapy
In modern immunotherapy, modified immune cells are introduced into the body to attack tumors and other targets. Researchers have now developed a method for tracking these cells in the body.

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The Same Technology Used in Cancer Immunotherapy Could Help Target Alzheimer’s
Inspired by cancer immunotherapy, scientists engineered immune cells equipped with specialized targeting devices called chimeric antigen receptors (CARs) that can distinguish and respond to tau tangles and various forms of toxic amyloid plaques.

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EGFR Inhibitors as a Solution for NF1-Mutant Melanoma
Increased activity in a specific biological pathway may explain why many patients with a deadly form of skin cancer do not respond to the latest cancer treatments, a new study shows.

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A New Tumor-Targeting System for Cancer-Fighting Cells
Researchers have developed new CAR-T cells to target malignant tumors. Their method targeted a protein found in high amounts on many types of cancer cells (Eva1) and successfully eliminated tumors in lab mice.
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