Cancer Immunology – News and Features

CAR T cells from older individuals have lower antitumor activity due to metabolic impairment, but researchers have been able to rejuvenate these cells by restoring NAD levels.

A group led by researchers at the A.C.Camargo Cancer Center has succeeded in improving CAR-T cells, making them more effective in treating refractory types of lymphoma and leukemia.

A study found that cancer survivors receiving high-cost immunotherapy treatments were more likely to face financial hardship, leading to increased instances of being unable to afford care and taking fewer medications due to cost.

Presenting at Technology Networks’ Cell and Gene Therapy 2025 Symposium, Dr. Andrew Mancini, senior corporate development manager at MaxCyte, shared his insights on how engineered cell therapies have evolved over the past eight years.

Early results from a clinical trial suggest that while denosumab does not directly reduce the proliferation of breast cancer cells, it may enhance the body’s immune response against tumors.

Scientists have developed an advanced gene editor – the evoCAST – that can add long stretches of DNA to defined locations in the human genome without creating unwanted modifications.

Researchers have developed a method to confidently produce blood cell precursors from stem cells in mice, representing a step towards restoring bone marrow in blood cancer patients.

UVA Health researchers developed a non-invasive focused ultrasound method with microbubbles that stops the growth of cerebral cavernous malformations (CCMs) in mice. The approach temporarily opens the blood-brain barrier without drugs.

Researchers have identified that the balance between two proteins – STAT3 and STAT5 – is important for making tumors vulnerable to immune checkpoint therapy and targeting STAT3 degradation is a potential novel cancer immunotherapy strategy.

Researchers have created a new kind of nanoparticle that could make ultrasound-based cancer treatments more effective and safer, while also helping prevent tumors from coming back.