Cancer Immunology – News and Features

In a Phase 1 clinical trial, a CAR T-cell therapy targeting the CD30 protein has been shown to promote the expansion of memory T cells, leading to durable responses and improved clinical outcomes in patients with refractory CD30+ lymphoma.

Today, our approach to irAE management is predominantly reactive. Clinical guidelines, while increasingly robust, are designed to detect and treat toxicity after it arises. This framework, though necessary, falls short of what is now possible.

A humanized antibody undermines the metabolic checkpoint mediated by CD36 to restore anti-tumor immunity in mouse models of hepatocellular carcinoma as well as liver metastases of colon cancer.

A new study from researchers at Moffitt Cancer Center shows that blocking a chemical process called nitrosylation could make one of the most aggressive forms of melanoma more treatable.

Researchers at Karolinska Institutet have uncovered a unique ability of a special subtype of natural killer cells in the immune system, called adaptive NK cells, to remember ovarian tumors and effectively attack them.

The tumor microenvironment is a harsh environment where metabolic adaptations are key. In this article, we explore how the metabolic constraints of the TME influence cancer and immune cells and dive into the metabolic cross-talk between them.

Traditionally, viruses have been thought of as a burden that cause disease. Now, viruses are being harnessed to tackle diseases that medicines can’t, helping fight cancer, genetic disorders and even infectious diseases.

Mapping a tumor's cellular neighborhood in three dimensions could identify potential targets for personalized cancer therapy.

“Cold” tumors are resistant to common immunotherapies. Stanford Medicine researchers have uncovered a master regulator that can be manipulated to prevent tumor growth in mice.

Tulane scientists found that an FDA-approved cancer drug may help the immune system clear out damaged cells that cause lung scarring, potentially restoring lung function in patients with pulmonary fibrosis.