Cell Culture – News and Features

Essential features of the cortex, an important part of the human brain and its development, have been more accurately captured in new organoids.

Two-dimensional liquid chromatography (2D-LC) offers extra separation power for complex and challenging samples and now has an important place in industry as well academia thanks to important advances. But this is by no means the end of the story.

A new multi-chamber organoid that mirrors the heart’s intricate structure enables scientists to advance screening platforms for drug development, toxicology studies and understanding heart development.

Gladstone Institutes researchers leveraged CRISPR to target and rapidly destroy glioblastoma cells in an approach that could carry over to other highly mutated cancers.

To identify potential therapeutic targets and preclinical drug candidates for the treatment of ovarian cancer, researchers have developed novel small molecule inhibitors of CPSF3, that catalyzes pre-mRNA splicing.

Intestinal organoids have helped to shine new light on the mechanisms behind stem cell differentiation, identifying a key step in the "switch" to different cell types.

A new drug developed for treating melanoma and lung cancer can also stop the progression of cutaneous squamous cell carcinoma, for which there are currently no targeted treatments.

The authors of the study say that caffeic-acid based carbon quantum dots – which can be derived from spent coffee grounds – have the potential to protect brain cells from damage.

A first-of-its-kind study led by the University of California, Irvine has revealed a new culprit in the formation of brain hemorrhages that does not involve injury to the blood vessels, as previously believed.

A team has now discovered a site in the DNA of cancer cells that is essential for leukemia cells to survive. Cancer cells in which the gene encoded at this site was modified experimentally died off.