Cell Culture – News and Features

Researchers from Gladstone Institutes and Stanford developed a genomic mapping method that links complex traits to the gene networks controlling them. The team identified how individual genes influence multiple biological pathways.

Researchers used CRISPR screening in tumor organoids and mice to identify two genes, Ctnna1 and Bcl2l13, that suppress colorectal cancer metastasis. One limits cell invasion, while the other triggers cell death after detachment.

MIT researchers have synthesized verticillin A, a complex fungal compound discovered more than 50 years ago and long recognized for its anticancer potential. The compound’s fragile structure and precise stereochemistry make it difficult to produce.

When exposed to green light, the protein AR3 increases alkalinity in cells, disrupting cellular functions and causing apoptosis.

The Spatial Touchstone project created a curated multi-tissue repository, standardized protocols and open-source tools to address quality gaps in spatial transcriptomics. The initiative enables researchers to evaluate sample quality.

Discover how cell-free DNA synthesis can accelerate mRNA vaccines and therapies, enhancing production efficiency and lowering contamination risks.

A new imaging approach combining AFM and fluorescence microscopy allowed researchers to observe influenza entry at high resolution. They discovered that cells recruit clathrin and reshape their membrane to capture viruses.

A new study describes a key molecular mechanism that explains how cells exchange information through extracellular vesicles.

Scientists have created a scalable 3D organoid model that captures key features of early limb development, revealing how a specialized signaling center shapes both cell identity and tissue organization.

Researchers have uncovered a specific form of epigenetic aging that leads to the shutdown of key genes in intestinal stem cells.