Cell Culture – News and Features

New research has offered insights into how tumor shape can predict cancer cell behavior and aggressiveness.

ETH Zurich researchers used combined CRISPR techniques to reveal unknown cancer-related mutations in the EGFR gene, identifying variants that may cause cancer or confer drug resistance.

University of California, Riverside scientists have designed novel agents that bind to and degrade Pin1, a protein linked to pancreatic cancer. These “molecular crowbars” destabilize Pin1, making it vulnerable to degradation.

Researchers at the University of Cincinnati found that copper accumulation fuels renal cell carcinoma by enhancing energy production in tumors. Elevated copper levels activate protective mechanisms that support cancer cell survival.

Using CRISPR-Cas13, NYU researchers reveal that noncoding RNAs, previously deemed “junk,” are crucial for cell function and development. Their findings, published in Cell, identify nearly 800 essential noncoding RNAs.

A team created UAB36, a polygenic score based on 36 genes linked to drug resistance, showing promise in predicting cancer treatment outcomes.UAB36 outperformed other scores, offering a potential tool for tailoring personalized cancer therapies.

Researchers have identified how mutations to CDK12 drive prostate cancer development and reported a promising treatment that targets the gene.

Stem cells grown in microgravity aboard the International Space Station (ISS) have unique qualities that could one day help accelerate new biotherapies.

Researchers have developed a continuously replicating model of human lip cells from donated tissue, overcoming challenges in lip research. This new model allows for extended study of lip biology, aiding in the understanding of lip conditions.

Researchers have designed a small molecule that holds promise as a cancer therapeutic, activating the apoptosis cascade in tumor cells while sparing healthy cells.