Cell Signaling – News and Features

Researchers have identified a novel strategy for treating an aggressive form of leukemia – reprogramming the cancer cells to induce differentiation.

A team from Fujita Health University developed a computational model to simulate the formation of protein condensates at synapses, revealing how proteins like CaMKII help organize memory structures in the brain.

As well as providing energy to the cell, glycolysis also controls cell fate in early embryonic development, laying the foundation for future organ development.

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling.

A study reveals that guinea pigs can serve as a robust model for understanding human pre-implantation development. Their similarities to humans in early embryogenesis open new avenues for infertility research and reproductive technologies.

Scientists at Johns Hopkins Medicine have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the activation of T cells to fight cancers and autoimmune diseases.

The mitochondrial protein that controls calcium transport could be a promising target for Alzheimer's and heart disease drugs.

New findings on how the gut microbiome influences drug metabolism and effectiveness could open the door to personalized medicines and better treatment outcomes.

Researchers at UCSF discovered that regulatory T cells (T-regs) in the meninges produce natural opioids, and their pain-suppressing effects are influenced by estrogen and progesterone.

Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death.