Clinical Omics – News and Features
GC-MS Principle, Instrument and Analyses and GC-MS/MS
Gas chromatography mass spectrometry (GC-MS) is an important technique in the analytical chemist's armory. In this article we explore how GC-MS and GC-MS/MS work, what they can tell us, their strengths, weaknesses and applications.
Whole-Genome Analysis of 12,000 Patients Reveals “Treasure Trove” of Cancer Insights
Scientists and clinicians from the University of Cambridge – supported by Cancer Research UK (CRUK) – have conducted the largest whole-genome sequencing analysis of cancer tumors to date.
Probing the Proteome With Engineered Nanoparticles
In this interview, Dr. Daniel Hornburg discusses how engineered nanoparticles could help to bridge the gap between proteomics and genomics and transform cancer diagnostics.
Advances in Proteomics
In this article, we will explore some of the recent advances in proteomics and their potential wider impact.
New Study Explores Potential Links Between Diet, Microbiome and Immune Response in Multiple Sclerosis
A new study has adopted a multi-omics methodology to explore potential links between diet, the microbiome and the immune response in multiple sclerosis (MS). The results are published in EBioMedicine.
Innovations in Single-Cell Proteomics Drive Advances in Disease Research
Single-cell technologies are transforming our knowledge of human health and disease. In this article, Gary Kruppa outlines the latest advances in single-cell proteomics.
Probing the Dark Matter of the Cancer Genome for Prognostic Biomarkers
Researchers have uncovered 166 prognostic biomarkers through machine learning analysis of long non-coding RNAs.
Insights Into Lung Tumor Biology and Potential Drug Targets
A team of researchers has developed the largest and most comprehensive molecular map to date of lung squamous cell carcinoma. The database, which brings proteomic, transcriptomic and genomic data together, can be used to find potential new drug targets and identify underlying disease mechanisms related to therapy resistance.
Mass Spectrometry Brings Resolving Power to Biopharma
In the early 20th century, mass spectrometry (MS) was used to measure the mass of atoms and demonstrate the existence of isotopes. Now, MS is used to study a broad range of molecules including small hydrocarbons, proteins, peptides, carbohydrates and DNA.
Probing Deep Into Tumor Tissues
Researchers have analyzed more than 8,000 proteins in detail from fixed samples of lung cancer tissue using mass spectrometers.