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CRISPR and Genome Editing – News and Features

Double helix structure of DNA.

Unlocking the Power of CRISPR Against RNA Viruses

Scientists have devised a new molecular tool that allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses.
Cancer cells.

Possible Therapeutic Target Identified for Small Cell Lung Cancer

Northwestern Medicine investigators have discovered that inhibiting a chromatin remodeling complex associated with a particular gene in small-cell lung cancer (SCLC) cells may decrease cancer cell differentiation and tumor growth.
Protein structure.

Protein That Controls CAR T-Cell Longevity Identified

In a new study, researchers have found that a protein called FOXO1 improves the survival and function of CAR T cells, which may lead to more effective CAR T cell therapies and could potentially expand its use in difficult-to-treat cancers.
Strand of orange mRNA on a blue background.
Industry Insight

Harnessing the Therapeutic Potential of Circular RNA

In this interview, Erik Digman Wiklund tells us about the discovery of circRNA and discusses some of the challenges of harnessing its full potential for therapeutic interventions.
Olive oil next to a plant on a table.

Potential Therapy Identified for Gene Mutation Associated With Increased Viral Infection Susceptibility

A gene mutation associated with a rare neurological disorder and increased susceptibility to viral infections may be treatable with oleic acid.
View of a petri dish with cholera bacteria (Vibrio cholerae).

Tiny RNA Molecules Play Key Role in Bacterial Defense Against Viruses

A research team has examined in detail the complex interaction of attack and defence strategies when cholera-causing bacteria are infected with a bacteriophage known as VP882 and discovered that tiny RNA molecules play a decisive role.
Histology of ovaries from healthy mice vs. mice without Usp7 gene.

Researchers Uncover Protein Networks in Female Mouse Reproduction

Scientists have found that while a protein called FOXL2 plays a role in embryonic development, it regulates the activity of many more genes after birth.
Computer-generated image of a DNA double helix.

Gene Editing Can Eliminate HIV From Cell Culture, Researchers Claim

The genome editing tool CRISPR-Cas9 can eliminate HIV viruses from lab-cultured cells, according to not-yet peer-reviewed research to be presented at this year’s European Congress of Clinical Microbiology and Infectious Diseases (ECCMID).
A digital illustration of a brain.

Researchers Target Brain Blood Vessels in Mice With COVID “Brain Fog”

Researchers have identified a mechanism that causes neurological problems in mice infected with the virus behind COVID-19, and also found a treatment that helped prevent these changes.
A crop field with an irrigation system.

Organic Farming Cuts Pesticide Use Locally, Spurs Rise Elsewhere

The impacts of organic farming are not fully understood, as a new study shows that organic farming significantly affects the amount of pesticide used in neighboring fields.