This page provides educational resources, events, news and products related to drug kinetics. Content will cover aspects from advances in drug-target binding research to factors affecting the a drug's performance and dosage.
Drug Kinetics – Highlights
New Frontiers in Pharmacokinetics
In this article, we look at two factors that may impact the pharmacokinetics of drugs; our gender, and the microbes we share our body with.
Drug Kinetics – Key Definitions
As biology presents ever-more challenging targets, those in the drug discovery field are pushing ahead with new tools to design or discover drugs that have optimal kinetics. But how familiar are you with the key terms used by scientists performing kinetics-directed drug design and discovery? Here, we have compiled a list of key definitions for your reference.
ADME Advances: Personalized and Computational Approaches
ADME profoundly affects a drug’s properties and has long been a cornerstone of pharmacology and drug discovery. Recent years, however, have seen an evolution in ADME concepts. Here, we take a closer look at the impact personalized and computational approaches are having on a drug's pharmacology.
Kinetics in Drug Discovery
Drugs elicit their desired therapeutic effects by interacting with specific disease-related targets. However, to determine exactly how a drug works inside the body it is important to address key questions. What type of drug is being used? How is it being administered? What are the characteristics of the individual taking the drug?
What’s the Best Way To Take 5-MeO-DMT in a Clinical Trial?
Beckley Psytech recently announced that they have dosed the first healthy volunteers in their Phase I trial of an intranasally delivered formulation of 5-MeO-DMT, named BPL-003. To find out more about their trial approach and wider research into 5-MeO-DMT, we spoke to Beckley’s chief scientific offer, Dr. Steve Wooding.
DNA Devices Safe To Use in Medical Applications
DNA folded into complex shapes that could be used to deliver medicine or create vaccines has been reported to be safe in mice.
Luminescent Gel Created With Applications From Counterfeiting to Biosensing
Scientists have taken inspiration from nature to create luminescent, self-healing gels with a suite of potential applications ranging from bank note counterfeiting to next-gen biosensing and imaging.
Encouraging Results From Clinical Trials of Two Male Contraceptive Pills
At ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, researchers present positive results from a study exploring acceptability and willingness to take two oral male contraceptive pills that are in clinical trials.
Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models
True High-Throughput Analysis of Transporter Activity Screens
Two key ADME (absorption, distribution, metabolism and excretion) properties used to predict the in -vivo performance of a drug candidate are its ability to permeate a cell membrane and its potential to act as a substrate for transmembrane transporter proteins.
Synthetic Immune Recruitment – A New Way To Fight Tumors
The utility and efficiency of the Octet® platform at characterizing covalent immune recruiter molecule function and their efficacy as modulators of protein proximity was demonstrated. Efficient in vitro validation further enables the potential acceleration of CIR translation to in vivo model validation and the clinic as a new class of synthetic tumor immunotherapeutic.