This page provides educational resources, events, news and products related to drug kinetics. Content will cover aspects from advances in drug-target binding research to factors affecting the a drug's performance and dosage.
Drug Kinetics – Highlights
ADME Advances: Personalized and Computational Approaches
ADME profoundly affects a drug’s properties and has long been a cornerstone of pharmacology and drug discovery. Recent years, however, have seen an evolution in ADME concepts. Here, we take a closer look at the impact personalized and computational approaches are having on a drug's pharmacology.
Kinetics in Drug Discovery
Drugs elicit their desired therapeutic effects by interacting with specific disease-related targets. However, to determine exactly how a drug works inside the body it is important to address key questions. What type of drug is being used? How is it being administered? What are the characteristics of the individual taking the drug?
What Is DMPK (Drug Metabolism and Pharmacokinetics)?
Today, the competitive landscape throughout the drug development process requires research scientists to apply rigorous qualitative and quantitative analyses to bring lead drug candidates to market in the shortest timeframe possible. In this article, we will discuss what is meant by drug metabolism and pharmacokinetics (DMPK) and explore its role in various stages of pharmaceutical development.
Assessing Kinetics in Drug Discovery
Download this listicle to learn more about the importance of drug kinetics, key experimental techniques and computational modeling tools.
The Promise of In Vitro 3D Organoid Models: Meeting the ADME-Tox Testing Needs of the Pharmaceutical Industry
For many years, biologists have relied on in vitro 2D cell culture models to perform preclinical ADME-Tox assays. While these models are useful, they are limited in their translatability to drug metabolism and toxicity in humans. Recently, in vitro 3D organoid models that more closely mimic human biological systems have shown promise in supporting ADME-Tox studies in drug discovery.
“Hit and Run” Therapeutic Eradicates Stomach Cancer in Mice
In mice treated with a novel cancer therapeutic, that combines antibody fragments with molecularly engineered nanoparticles, gastric cancer was permanently eradicated.
Light-Induced System Accelerates Drug Delivery Into Cells
A new system that uses light to help transport drugs into cells has been developed and has been shown to effectively deliver drugs to target cells.
Advanced Oncology Treatment Candidates Developed With Next-Generation Preclinical Models
In this article, we explore the role of preclinical models in oncology drug discovery and how the right model can help to accelerate the development of the most promising treatments.
The Pulse: Psychedelic News From Technology Networks
In the Pulse, the monthly psychedelics industry roundup from Technology Networks and Analytical Cannabis, we highlight some of the most significant psychedelic industry news from the past month. This includes important announcements, pre-clinical work and the latest from groundbreaking psychedelic clinical trials.
Highlights of the In Vitro Sections of the Draft ICH Drug Interaction Studies Guideline and Comparison with Current Guidance
Precision qPCR and dPCR in the Discovery and Development of Cell and Gene Therapies
App Note / Case Study
Reach New Levels of Metabolite Characterization
Early ADME studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation. Glucuronide conjugation is difficult to characterize using MS/MS alone, therefore fragmentation is also required to obtain structural information.
CN Bio Extends Microphysiological System Portfolio
CN Bio has announced the commercial launch of the PhysioMimix™ Single-organ Higher Throughput System.