Drug Kinetics – Multimedia
ADME 101 Guide to Subcellular Fractions and When to Use Which Test System
This ADME 101 video provides an overview of different types of subcellular fractions, such as microsomes, S9, cytosol, lysosomes and homogenate, and their unique benefits for use in various types of in vitro ADMET/DMPK & Drug-Drug Interaction studies.
ADMET in Drug Discovery With Dr. Andrew Mtewa
In this Teach Me in 10 episode, Lucy Lawrence is joined by Dr. Andrew Mtewa, senior lecturer in chemistry at the Malawi University of Science and Technology.
Human Organs-on-Chips for Disease Modeling, Drug Development and Personalized Medicine
Speaking at the online symposium, Innovations in Disease Modeling 2022, Dr. Donald E. Ingber, Founding Director of Wyss Institute for Biologically Inspired Engineering at Harvard University, presented his talk on novel human organ-on-a-chip technologies
Role of Sulfotransferases in Drug Metabolism and Potential for Drug Drug Interactions
Continuing our series on non-CYP-mediated metabolism pathways, we will be discussing another of the most requested enzymes: Sulfotransferases (SULTs). SULTs participate in Phase 2 metabolism of xenobiotics in humans and are characterized by the abundance and broad tissue distribution of the enzymes. Gene regulation and genetic polymorphism of SULTs also contribute to our understanding of the significance of these enzymes in the process of drug development.
In Vitro DDI Drug Transporter Studies | ADME 101 Webinar: Efflux and Uptake Transporters
Drug transport can be thought of as the AD&E in ADME, as transporters are responsible for absorption, distribution, tissue-specific drug targeting, and elimination of drugs. Since they are involved in so much of the movement of a compound through the body, they can be involved in many drug‒drug interactions (DDI). The clearance of transporter substrates can be impacted by transporter inhibitors or inducers which can lead to toxicity or loss of efficacy.
Drug Discovery and Design
Download this eBook to explore automation in drug discovery, therapeutic targets, drug delivery, novel approaches to treatment and various screening strategies.
ADME 101 Guide: Which Hepatocyte Test System Should I Use?
This ADME 101 video provides an overview of different types of hepatocytes, their unique benefits, and when you use them for in vitro preclinical DMPK studies.
Assessing Kinetics in Drug Discovery
Download this listicle to learn more about the importance of drug kinetics, key experimental techniques and computational modeling tools.
Navigating the Use of Extracellular Vesicles as Therapeutics
Download this listicle to learn more about extracellular vesicles as engineerable drug delivery vehicles, vaccines and from mesenchymal stem cells.
Addressing Unique Challenges With Custom In Vitro Test Systems
In this webinar, Products Director and custom test system expert, Zell Woodworth, will discuss some of the unique challenges his team have solved and the ways custom solutions are designed and executed to help researchers and drug developers meet goals outside the reach of standard in vitro products.