Drug Kinetics – Multimedia

This ADME 101 video discusses how compounds can become trapped by lysosomes, which can lead to high organ-to-blood ratios and mistaken for active drug transport, how concomitant administration of lysosomotropics could lead to elevated drug exposure levels, and how accumulation of lipophilic amines can lead to drug-induced phospholipidosis due to decreased phospholipid catabolism.

This ADME 101 video provides an overview of different types of subcellular fractions, such as microsomes, S9, cytosol, lysosomes and homogenate, and their unique benefits for use in various types of in vitro ADMET/DMPK & Drug-Drug Interaction studies.

In this Teach Me in 10 episode, Lucy Lawrence is joined by Dr. Andrew Mtewa, senior lecturer in chemistry at the Malawi University of Science and Technology.

Speaking at the online symposium, Innovations in Disease Modeling 2022, Dr. Donald E. Ingber, Founding Director of Wyss Institute for Biologically Inspired Engineering at Harvard University, presented his talk on novel human organ-on-a-chip technologies

Continuing our series on non-CYP-mediated metabolism pathways, we will be discussing another of the most requested enzymes: Sulfotransferases (SULTs). SULTs participate in Phase 2 metabolism of xenobiotics in humans and are characterized by the abundance and broad tissue distribution of the enzymes. Gene regulation and genetic polymorphism of SULTs also contribute to our understanding of the significance of these enzymes in the process of drug development.

Drug transport can be thought of as the AD&E in ADME, as transporters are responsible for absorption, distribution, tissue-specific drug targeting, and elimination of drugs. Since they are involved in so much of the movement of a compound through the body, they can be involved in many drug‒drug interactions (DDI). The clearance of transporter substrates can be impacted by transporter inhibitors or inducers which can lead to toxicity or loss of efficacy.

Download this eBook to explore automation in drug discovery, therapeutic targets, drug delivery, novel approaches to treatment and various screening strategies.

This ADME 101 video provides an overview of different types of hepatocytes, their unique benefits, and when you use them for in vitro preclinical DMPK studies.

Download this listicle to learn more about the importance of drug kinetics, key experimental techniques and computational modeling tools.

Download this listicle to learn more about extracellular vesicles as engineerable drug delivery vehicles, vaccines and from mesenchymal stem cells.