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Drug Kinetics – Webinars and Online Events

Webinar

Every Breath You Take: Predicting Inhaled Drug ADME Using Lung-on-a-Chip

On-Demand
The administration of drugs via inhalation into the lungs is superior to many other methods of delivery because our lungs provide a large surface area for absorption, access to the whole blood volume and comparatively little metabolic activity. Currently, there are limited in vitro models in which the absorption and permeability of drugs across the lung and into systemic circulation can be precisely measured.

In this webinar, Dr. Emily Richardson will describe novel lung-on-a-chip (LOAC), otherwise known as lung microphysiolological system, models of the alveoli and bronchi which can be used to accurately predict drug pharmacokinetics, allowing for more rapid, precise and cost-effective analysis of compounds.

Webinar

Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models

On-Demand
An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.
Webinar

Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Presentation

On-Demand
We will explore how these advances are being utilized, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.
Webinar

Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Presentation

On-Demand
We will explore how these advances are being utilized, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.
Webinar

From Dose to Circulation – Determination of Drug Oral Bioavailability Using a Gut–Liver Microphysiological System

On-Demand
In this webinar, Dr. Yassen Abbas will discuss how CN-Bio’s gut–liver MPS can be used for in vitro determination of oral bioavailability.
Webinar

Liver-on-Chip and In Silico Modeling for Quantitative Drug Metabolism Studies

On-Demand
This webinar will examine the benefits of combining LOAC with in silico modeling to explore clinical PK predictions of specific reference drugs, including investigations into the intrinsic clearance determinations for high metabolically stable compounds and the quantitation of fractions metabolized by specific enzymes.
Webinar

Bringing Life to PK Profiles – In Vivo-Relevance From an In Vitro Environment

On-Demand
In drug development, microphysiological systems (MPS) are utilized to develop in vitro biological models that can generate more physiologically- and human-relevant data.
Webinar

Formulating a New Approach to Pharmacokinetics and Cell State Control

On-Demand
Most in vitro, well-plate biological experiments require a media change every day or two, with cyclic variations in nutrient and metabolite concentrations leading to physiologically unrealistic gene expression and metabolism.
Webinar

Towards a Body-on-a-Chip: The Value of Multi-Organ MPS for Human-Relevant Drug Assessment

On-Demand
Microphysiological Systems (MPS), also known as organ-on-a-chip, generate human-relevant 3D cell culture models whose phenotypes and functions mimic individual in vivo organs. When therapeutics are added, these models can generate results that translate into clinical outcomes more reliably than standard in vitro techniques.
Webinar

Testing on Humans: How To Predict Hepatotoxicity and Drug Clearance Ahead of Clinical Trials Using Liver-on-a-Chip

On-Demand
Current in vitro approaches for investigational toxicology, drug metabolism (DMPK) and safety are limited and are not fully representative of human response; therefore, drugs showing acceptable preclinical toxicity often fail in human clinical trials, and accurately predicting human drug exposure for new compounds is challenging and costly.
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