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Drug Targets – News and Features

Holographic image of human body with pancreas shown in red.
News

Immune Mapping of Pancreatic Cancer Offers Insights for Precision-Targeted Treatment

Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumors may potentially be more susceptible to macrophage-based therapies.
A researcher pipettes pink cell culture medium into a six-well plate, next to a stack of petri dishes filled with medium.
News

Researchers Engineer Living Materials With Unique Properties

Researchers have revealed novel sequence-structure-property relationships for customizing engineered living materials, enabling more precise control over their structure and how they respond to force.
A blue DNA helix with a section in red that looks like it's falling apart.
News

Mutations Point to Promising Drug Target in 5% of Adult Cancers

Researchers have discovered that about 5% of adult cancers rely on a gene called PELO to survive, offering a promising drug target.
A drug capsule.
News

Antibiotic Resistance Can Develop Before Drugs Hit the Market

Scientists in Hungary found that antibiotic resistance can emerge before new drugs are even in clinical use. The study highlights pre-existing bacterial mutations that render new treatments ineffective.
Orange and white pills spill from a prescrip[tion bottle.
News

Photopharmacology Helps Identify a New Anxiety Drug Target

Researchers have identified a specific brain circuit that, when inhibited, reduces anxiety without any side effects.
HIV attacking a human cell.
News

Blushwood Compound Offers Hope for HIV Cure Through "Kick and Kill" Strategy

Stanford researchers highlight the potential of EBC-46, a compound derived from Australia’s blushwood tree, in eradicating HIV. EBC-46 activates dormant virus cells, enabling targeted therapies to clear infections.
A drug capsule filled with small beads, with cells in the background.
Article

The Impact of Functional Genomics in Drug Discovery

Functional genomics can help deconvolute the link between genotype and phenotype in disease, revealing new drug targets and progressing understanding of existing drugs.
 A map showing areas of Nipah virus infections in bats and humans across the world.
News

Critical Component of Nipah Virus Mapped for the First Time

Harvard and Boston University researchers mapped the Nipah virus polymerase, a key protein for viral replication, using cryo-electron microscopy. The study identifies potential drug targets.
A stretch of DNA, with one section illuminated.
News

Two Genes Driving Early Prostate Tumor Formation Discovered

Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer development.
HIV cells attacking a human cell.
News

HIV-1's Secret RNA Structures Offer Clues for Fighting the Virus

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site structure that regulate viral protein synthesis. These findings highlight ribosome pausing as a key mechanism.
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