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Drug Targets – News and Features

A schematic showing how cancer gene's RNA can be targeted.

New RNA Degrader Approach Tackles the “Mount Everest” of Cancer Targets

The "Mount Everest" of cancer genes, MYC, has been targeted by a new RNA degrader approach, where cellular recycling enzymes are directed to cancer gene RNA to remove key segments.
A person holding their face in pain.

The Genetic Root of a Woman’s Inability To Feel Pain Has Been Identified

The biology underpinning a rare genetic mutation that allows its carrier to live virtually pain-free, heal more rapidly and experience reduced anxiety and fear, has been uncovered by new research from UCL.
Floating cancer cells.

Protein Hyperactivation Could Kill Cancer Cells and Bacteria

Technology Networks had the pleasure of speaking with Walid A. Houry, professor of biochemistry at the University of Toronto, to find out about the discovery of compounds that can induce protease hyperactivation to kill cancer cells.
A cell that is about to rupture due to programmed cell death.

How Do Our Cells Kill Themselves?

Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture.
A mosaic of yellow, red and blue shapes.

Pancreatic Cancer Cells Switch Fuels in the Absence of Sugar in Mice

Cancer cells can adapt to use uridine as a fuel source when access to glucose is limited, reports a new study from the University of Michigan.
A brain made of computer-like components.

AI Deep Dives Could Reveal Drug Targets for Alzheimer's Cure

Artificial intelligence is helping researchers identify causes of Alzheimer’s disease and potential drug targets by looking deep into the human brain to map the molecular changes that healthy neurons undergo with disease progression.
Microglia surrounding an ARG1+microglia cell.

Diversity Among Immune Cells in the Brain Revealed

According to research, ARG1+microglia, a subset of microglial cells that produce the enzyme arginase-1 (ARG1), are abundant during development and less prevalent in adult animals.
Microscope image of microglia surrounding an ARG1+microglia cell.

Immune Cells of the Brain Are Not All the Same

A new study sheds light on the importance of microglia, the immune cells of the brain, in cognition and memory. Understanding the biology of these cells could provide new directions to treat many currently untreatable diseases of the brain.
An image depicting a visual hallucination.

African Psychedelic Plant Inspires Two New Depression Drugs

Modeling the pharmacological properties of the African psychedelic plant medicine ibogaine, researchers have developed two novel drug candidates for treating addiction and depression. The research is published in Cell.
A reflection of a hand touching a mirror.

“Mirror Image” Molecules Identify Potential Cancer Drug Targets

Scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.