Drug Targets – News and Features

Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

Blocking oxygen-sensing enzymes in cancer cells can significantly halt acute myeloid leukemia in patient samples without affecting the production of normal blood cells.

Using a novel imaging technique to view cells in 3D, researchers have been able to identify two genes that control how melanoma skin cancer cells change shape – offering potential drug targets to prevent the cancer from spreading.

At ELRIG’s Research & Innovation 2024 event, Technology Networks spoke to Dr. Véronique De Conto, project leader in in vitro pharmacology at HCS Pharma, to learn more about their powerful tools for in vitro metastasis propagation.

Recently approved Alzheimer's drugs work by tagging amyloid plaques for clearance by the brain's microglia. Washington University School of Medicine in St. Louis researchers are developing an alternative approach, using a homemade antibody to directly mobilize microglia.

Columbia researchers have discovered a genetic variant that reduces the odds of developing Alzheimer’s disease by up to 70% and may be protecting thousands of people in the United States from the disease.

A University of Oklahoma study about a “black box warning” for the asthma drug Singulair continues to influence a national conversation about the medication and its reported neuropsychiatric side effects in children and adolescents.

Cambridge researchers have identified genetic variants in two genes that have some of the largest impacts on obesity risk discovered to date.

Researchers have developed a process to bioengineer heparin, the world’s most widely used blood thinner, which is currently derived from pig intestines.

Researchers have identified two enzymes that work against the chemotherapy drug gemcitabine, preventing it from treating pancreatic cancer.