Drug Targets – News and Features

The "Mount Everest" of cancer genes, MYC, has been targeted by a new RNA degrader approach, where cellular recycling enzymes are directed to cancer gene RNA to remove key segments.

The biology underpinning a rare genetic mutation that allows its carrier to live virtually pain-free, heal more rapidly and experience reduced anxiety and fear, has been uncovered by new research from UCL.

Technology Networks had the pleasure of speaking with Walid A. Houry, professor of biochemistry at the University of Toronto, to find out about the discovery of compounds that can induce protease hyperactivation to kill cancer cells.

Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture.

Cancer cells can adapt to use uridine as a fuel source when access to glucose is limited, reports a new study from the University of Michigan.

Artificial intelligence is helping researchers identify causes of Alzheimer’s disease and potential drug targets by looking deep into the human brain to map the molecular changes that healthy neurons undergo with disease progression.

According to research, ARG1+microglia, a subset of microglial cells that produce the enzyme arginase-1 (ARG1), are abundant during development and less prevalent in adult animals.

A new study sheds light on the importance of microglia, the immune cells of the brain, in cognition and memory. Understanding the biology of these cells could provide new directions to treat many currently untreatable diseases of the brain.

Modeling the pharmacological properties of the African psychedelic plant medicine ibogaine, researchers have developed two novel drug candidates for treating addiction and depression. The research is published in Cell.

Scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.