Drug Targets – News and Features

News
Immune Mapping of Pancreatic Cancer Offers Insights for Precision-Targeted Treatment
Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumors may potentially be more susceptible to macrophage-based therapies.

News
Researchers Engineer Living Materials With Unique Properties
Researchers have revealed novel sequence-structure-property relationships for customizing engineered living materials, enabling more precise control over their structure and how they respond to force.

News
Mutations Point to Promising Drug Target in 5% of Adult Cancers
Researchers have discovered that about 5% of adult cancers rely on a gene called PELO to survive, offering a promising drug target.

News
Antibiotic Resistance Can Develop Before Drugs Hit the Market
Scientists in Hungary found that antibiotic resistance can emerge before new drugs are even in clinical use. The study highlights pre-existing bacterial mutations that render new treatments ineffective.

News
Photopharmacology Helps Identify a New Anxiety Drug Target
Researchers have identified a specific brain circuit that, when inhibited, reduces anxiety without any side effects.

News
Blushwood Compound Offers Hope for HIV Cure Through "Kick and Kill" Strategy
Stanford researchers highlight the potential of EBC-46, a compound derived from Australia’s blushwood tree, in eradicating HIV. EBC-46 activates dormant virus cells, enabling targeted therapies to clear infections.

Article
The Impact of Functional Genomics in Drug Discovery
Functional genomics can help deconvolute the link between genotype and phenotype in disease, revealing new drug targets and progressing understanding of existing drugs.

News
Critical Component of Nipah Virus Mapped for the First Time
Harvard and Boston University researchers mapped the Nipah virus polymerase, a key protein for viral replication, using cryo-electron microscopy. The study identifies potential drug targets.

News
Two Genes Driving Early Prostate Tumor Formation Discovered
Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer development.

News
HIV-1's Secret RNA Structures Offer Clues for Fighting the Virus
Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site structure that regulate viral protein synthesis. These findings highlight ribosome pausing as a key mechanism.
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