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Drug Targets – News and Features

A white blood cell.

Promising Treatment Approach for Aggressive Leukemia Identified

Blocking oxygen-sensing enzymes in cancer cells can significantly halt acute myeloid leukemia in patient samples without affecting the production of normal blood cells.
Enhanced scanning electron microscopy (SEM) image of cancer malignant cells with high magnification of the cells surface

Cancer Cells’ Shapeshifting Ability Reveals New Drug Targets

Using a novel imaging technique to view cells in 3D, researchers have been able to identify two genes that control how melanoma skin cancer cells change shape – offering potential drug targets to prevent the cancer from spreading.
A lab worker pipetting media into a cell culture dish.
Industry Insight

Recreating Organ-Specific Tumor Environments In Vitro

At ELRIG’s Research & Innovation 2024 event, Technology Networks spoke to Dr. Véronique De Conto, project leader in in vitro pharmacology at HCS Pharma, to learn more about their powerful tools for in vitro metastasis propagation.
High magnification micrograph of microglia cells stained with Rio-Hortega's method (silver carbonate). This type is the ramified or resting microglia that appears in normal brain tissue.

Mobilizing Microglia in the Fight Against Alzheimer’s Disease

Recently approved Alzheimer's drugs work by tagging amyloid plaques for clearance by the brain's microglia. Washington University School of Medicine in St. Louis researchers are developing an alternative approach, using a homemade antibody to directly mobilize microglia.
A 3D model of a human brain.

A New Genetic Variant That Protects Against Alzheimer’s

Columbia researchers have discovered a genetic variant that reduces the odds of developing Alzheimer’s disease by up to 70% and may be protecting thousands of people in the United States from the disease.
White pills on a blue background.

Study Sheds Light on Side Effects for Children Taking Asthma Drug

A University of Oklahoma study about a “black box warning” for the asthma drug Singulair continues to influence a national conversation about the medication and its reported neuropsychiatric side effects in children and adolescents.
Double helix structure of DNA.

Genetic Variants in Two Genes Finds Six-Fold Impact on Obesity Risk

Cambridge researchers have identified genetic variants in two genes that have some of the largest impacts on obesity risk discovered to date.
A blue-green pill in the middle of white tablets.

Discovery May Reduce Dependence on Animals for Anti-Clotting Drug

Researchers have developed a process to bioengineer heparin, the world’s most widely used blood thinner, which is currently derived from pig intestines.
Pills spill form a prescription bottle.

Issue Hampering Pancreatic Cancer Drug Combination Identified

Researchers have identified two enzymes that work against the chemotherapy drug gemcitabine, preventing it from treating pancreatic cancer.
Cancer cells.

Targeting Cancer-Fueling Proteins Shows Potential for Treating Aggressive Leukaemia

Researchers have found a new way to potentially treat one of the most common forms of acute lymphoblastic leukaemia. The study was able to kill leukaemia cells in the lab and stop cancer cells from growing.