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Drug Targets – News and Features

A bacteriophage.

First Look at Atom-Level Structure of Packaged Viral Genome

The first atom-level model of a DNA-packed viral capsid reveals genome structure and possible new drug targets, University of Illinois researchers report.
An anxious young woman with her head in her hands.

Genetic “Switch” Controlling Anxiety Discovered

A genetic "switch" has been identified that plays a role in controlling anxiety levels, which researchers hope could provide a new anxiety drug target.
A row of pipettes filled with red liquid

High-Throughput Screening: Advances, Applications and Combined Approaches

In this article, we highlight various high-throughput screening strategies being used to interrogate large libraries of compounds and hear from researchers working to further streamline specific approaches to increase speed and improve quality and accuracy.
A strand of RNA.

Study Finds Why Some RNA Drugs Are More Effective Than Others

The field of RNA therapeutics is booming. But not all drugs are created equal. CSHL scientists Justin Kinney and Adrian Krainer recently teamed up to investigate why some RNA-splicing-based therapies work better than others.
White pills on a blue background.

Regenerative Hearing Drug Assessed in World-First Trial

UCL and UCLH researchers have successfully completed a world-first trial of a therapy designed to restore hearing loss.
A male patient with a doctor.

Understanding the Genetics of Male Breast Cancer

Male breast cancer represents less than 1 percent of all breast cancer cases each year. Unlike breast cancer in women, survival rates for men haven't significantly improved in the last 30 years, according to the National Cancer Institute.
A network of icons indicating connections in technology.
Industry Insight

Using Predictive Tools To Bring Drugs to Market Faster

We spoke to Olivier Barberan, director of Translational Medicine Solutions at Elsevier, to find out more about how predictive tools can inform pharma companies and help pave the way for drugs to get to market.
Various pills on a table with a magnifying glass over one, bringing into focus.

Drug Repurposing Strategies, Challenges and Successes

In this article, we explore the evolution of drug repurposing from a serendipitous occurrence to a more formalized endeavor involving advanced computational approaches and bioengineered test beds, considering its advantages, challenges and successes.
A selection of pills and capsules in different shapes and colors.

Streamlined Drug Discovery Approach Proposed by Researchers

New research points to a streamlined approach to drug discovery that allows drug makers to determine the viability of a fragment-based design earlier in the process.
A sign reading "ALS".

New Cell Culture Model Identifies Potential ALS Drug Target

Using the new cell culture model "iNets", University of Zurich researchers identified a missing link between aberrant TDP-43 behavior and neuronal cell death: a toxic accumulation of NPTX2, a protein that is usually secreted through the synapses.