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Drug Targets – News and Features

White pills coming out of a pink pill bottle.
News

Immune System-Targeting Drug Shows Early Promise for Lupus

Scripps Research scientists developed a compound that can block a protein previously considered challenging to drug and is implicated in autoimmune diseases, including lupus..
Various oral medicines falling onto a tabletop.
Article

Understanding Binding Kinetics To Optimize Drug Discovery

The efficacy of a drug candidate not only depends on the drug–target binding affinity, but also on the binding kinetics. This article outlines why studying drug binding kinetics is important in drug discovery, covering key approaches to measure the drug–target kinetics.
Orange and white drug capsules spill from a prescription bottle.
News

Epilepsy Drug May Show Promise in Slowing Osteoarthritis Joint Breakdown

A drug currently used to treat epilepsy may also reduce joint damage in osteoarthritis, by inhibiting a protein that blocks collagen production.
Teal and white drug capsules on a pink background.
News

Schizophrenia Medication's Potential Mechanism of Action Revealed

The mechanism of action of the schizophrenia drug asenapine has been revealed, paving the way to improved medications that target the same pathway.
A microscope lens pointed at a slide.
News

New Findings on GPCR Structure

An atomic-level investigation has revealed how each amino acid in GPCR contributes to receptor activity in the presence of ligands.
Prostate cancer cells, in an early stage on the left and more cancerous on the right.
News

Role of Enzyme in Prostate Cancer Progression Identified

The role of the SMYD3 enzyme in driving prostate cancer progression has been identified, making it a prime drug target for preventing metastatic disease.
Double helix structure of DNA.
News

Next-Gen CRISPR Tool Produces Unprecedented Map of Human Immune Response

In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.
A clinician holds a brain scan.
News

New Molecule Protects the Brain in Animal Models of Multiple Sclerosis

Pre-clinical studies using a small molecule drug have shown promise as a potential new treatment for multiple sclerosis.
A mosquito.
News

How Zika Virus Does So Much With So Little

Researchers at Sanford Burnham Prebys have shown how the virus Zika does so much with so little and may have identified a therapeutic vulnerability.
A scientist holding up a vial.
News

Scientists Find a Method To Predict Which of Our Organs Will Fail First

A new study led by Stanford Medicine scientists demonstrates a simple way of studying organ aging by analyzing distinct proteins, or sets of them, in blood, enabling the prediction of individuals’ risk for diseases.
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