Gene and Cell Therapy – News and Features

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Squeezing Through Narrow Spaces Prompts Stem Cells To Turn Into Bone Cells
In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

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Magnetic Nanoparticles Steer Brain Cells To Rebuild Lost Connections
Researchers have developed a novel approach that uses magnetically guided mechanical forces to direct axonal growth, aiming to enhance the effectiveness of stem cell-based therapies for Parkinson's disease and other neurological conditions.

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Scientists Improve Liver Organoids for Research Into Hemophilia
Researchers have created liver tissue that grows its own blood vessels, improving research into hemophilia and liver damage.

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Why Humans Are More Susceptible to Cancer
Researchers at the University of California Davis Comprehensive Cancer Center have uncovered an evolutionary change that may explain why human immune cells are less effective at combating solid tumors compared to our closest living ancestors.

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Patterned Culture Dish Elevates Stem Cell Therapy Potential
Researchers developed a method to grow mesenchymal stem cells as aligned sheets using a patterned culture dish. This setup increases secretion of key cytokines linked to healing and immune regulation.

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CRISPR Tool Accounts for Genetic Variability To Improve Predictions
A new tool, Variant-aware Cas-OFFinder, enhances CRISPR-Cas9 predictions by factoring in genetic variations like SNPs and deletions. It provides more accurate, personalized genome editing strategies for humans and plants.

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Mutations in Blood Stem Cells May Protect Against Alzheimer’s
Researchers at Baylor College of Medicine discovered that mutations in the TET2 gene in blood stem cells could protect against late-onset Alzheimer’s disease. The study showed that TET2-mutant cells help clear beta-amyloid plaques.

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Dystroglycan Plays a Key Role in Connections Between Nerve Cells
New research reveals that the protein Dystroglycan plays a critical role in forming and maintaining connections between nerve cells in the cerebellum.

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OTOF Gene Therapy Successfully Improves Hearing in Clinical Trial
Researchers tested a gene therapy that restored partial hearing in patients with OTOF gene mutations causing congenital deafness. The therapy delivered a functional OTOF gene using an adeno-associated virus (AAV) injection.

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“Leukemia-on-a-Chip” Offers a New Tool for Screening CAR T-Cell Therapy
Researchers have pioneered a novel 3D platform that mimics the human bone marrow and immune environment, enabling more predictive testing of cancer immunotherapy success in patients, including CAR T cell therapies.
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